topic 8 pk: mechanisms of drug absorption
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6 Terms
what are the mechanisms of drug absorption? (5)
aqueous diffusion
lipid diffusion
carrier-mediated transport
endocytosis
exocytosis
what is aqueous diffusion?
passive movement through aqueous channels in the membrane
what is lipid diffusion?
passive diffusion directly through the lipid membrane
what is carrier-mediated transport? (2)
membrane protein assist movement
may be facilitated diffusion or active transport
what is endocytosis? (2)
cell membrane engulfs and internalises the substance
into the cell
what is exocytosis? (2)
an intracellular vesicle fuses with the membrane and release contents outside the cell
mainly used for release not drug absorption