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Depression
A low, sad state marked by significant levels of sadness, lack of energy, low self-worth, guilt, or related symptoms.
Mania
A state or episode of euphoria or frenzied activity in which people may have an exaggerated belief that the world is theirs for the taking.
Depressive Disorders
The group of disorders marked by unipolar depression.
Unipolar Depression
Depression without a history of mania.
Bipolar Disorder
A disorder marked by alternating or intermixed periods of mania and depression.
Anhedonia
An inability to experience any pleasure at all.
Major Depressive Disorder
A severe pattern of depression that is disabling and not caused by such factors as drugs or a general medical condition.
Persistent Depressive Disorder
A chronic form of unipolar depression marked by ongoing and repeated symptoms of either major or mild depression.
Premenstrual Dysphoric Disorder
A disorder marked by repeated episodes of significant depression and related symptoms during the week before menstruation.
Disruptive Mood Dysregulation Disorder
A disorder characterized by a combination of persistent depressive symptoms and recurrent outbursts of severe temper.
Norepinephrine
A neurotransmitter whose abnormal activity is linked to depression and panic disorder.
Serotonin
A neurotransmitter whose abnormal activity is linked to depression, obsessive-compulsive disorder, and eating disorders.
Glutamate
A neurotransmitter responsible for stimulating neurons and promoting connectivity and communication among neurons.
HPA Axis (Hypothalamic-Pituitary-Adrenal Axis)
One of the stress-related routes throughout the brain and body that ultimately brings about the release of hormones at various locations throughout the body. Induce a heightened state of arousal.
Cortisol
A type of hormone.
Depression-Related Brain Circuit
Includes brain structures such as the prefrontal cortex, hippocampus, amygdala, and subgenual cingulate (Brodmann Area 25).
Lymphocytes
An important type of white blood cells.
Pro-Inflammatory Cytokines
Proteins that spread throughout the body and cause inflammation and various illnesses.
MAO (Monoamine Oxidase) Inhibitor
An antidepressant drug that prevents the action of the enzyme monoamine oxidase.
Tricyclic
An antidepressant drug such as imipramine that has three rings in its molecular structure.
Reuptake
A pump-like mechanism in the neuron’s ending that immediately starts to reabsorb neurotransmitters.
SSRIs (Selective Serotonin Reuptake Inhibitors)
A group of second-generation antidepressant drugs that increase serotonin activity specifically, without affecting other neurotransmitters.
Ketamine
An anesthetic drug that is also used as an antidepressant, bringing rapid relief to many people with depression.
Brain Stimulation
Treatments that directly or indirectly stimulate certain areas of the brain.
Electroconvulsive Therapy (ECT)
A treatment for depression in which electrodes attached to a patient’s head send an electrical current through the brain, causing a convulsion.
Vagus Nerve Stimulation
A treatment for depression in which an implanted pulse generator sends regular electrical signals to the vagus nerve; the nerve then stimulates the brain.
Transcranial Magnetic Stimulation (TMS)
A treatment in which an electromagnetic coil, which is placed on or above a patient’s head, sends a current into the individual’s brain.
Deep Brain Stimulation (DBS)
A treatment for depression in which a pacemaker powers electrodes that have been implanted in the subgenual cingulate, thus stimulating that brain area.
Symbolic Loss
According to Freudian theory, the loss of a valued object (for example, a loss of employment) that is unconsciously interpreted as the loss of a loved one. Also call imagined loss.
Cognitive Triad
The three forms of negative thinking that Aaron Beck theorizes lead people to feel depressed. The triad consists of a negative view of one’s experiences, oneself, and the future.
Automatic Thoughts
Numerous unpleasant thoughts that help to cause or maintain depression, anxiety, or other forms of psychological dysfunction.
Rumination
Repeatedly dwelling mentally on mood without acting to change it.
Learned Helplessness
The perception, based on past experiences, that one has no control over the reinforcements in one’s life.
Behavioral Activation
A therapy for depression in which the therapist works systematically to increase the number of constructive and pleasurable activities and events in a client’s life.
Cognitive Therapy
A therapy developed by Aaron Beck that helps people identify and change the maladaptive assumptions and ways of thinking that help cause their psychological disorders.
Interpersonal Psychotherapy (IPT)
A treatment for unipolar depression that is based on the belief that clarifying and changing one’s interpersonal problems helps lead to recovery.
Couple Therapy
A therapy format in which the therapist works with two people who share a long-term relationship.
Culture-Sensitive Therapies
A form of therapy designed to address the unique issues faced by members of cultural minority groups.
Developmental Psychopathology
A perspective of psychology that views psychological disorders as a combination of factors.
Protective Factors
Also called “positive factors”.
Resilience
An important protective factor in which one is better able to withstand stresses in life.
Hypomanic Episode
When symptoms of mania are less severe (causing little impairment).
Bipolar I Disorder
A type of bipolar disorder marked by full manic and major depressive episodes. (Alternation of the episodes.)
Bipolar II Disorder
A type of bipolar disorder marked by a mildly manic (hypomanic) episodes and major depressive episodes.
Cyclothymic Disorder
A disorder marked by numerous periods of hypomanic symptoms and mild depressive symptoms. (Continues for 2 or more years, interrupted occasionally by normal moods that may last for only days or weeks.)
Ions
Play a critical role in relaying messages within a neuron. They also help transmit messages down the neuron’s axon to the nerve endings.
Lithium
A metallic element that occurs in nature as a mineral salt and is an effective treatment for bipolar disorders.
Mood-Stabilizing Drugs
Psychotropic drugs that help stabilize the moods of people suffering from bipolar disorder. Also known as antibipolar drugs.
Second Messengers
Substances in the neuron that carry out changes by relaying the original message from the receptor site to the firing mechanism of the neuron.
Brian-Derived Neurotrophic Factor (BDNF)
A protein whose job is to prevent cell death.
Adjunctive Psychotherapy
A therapy used to emphasize the importance of continuing to take medications, improve social skills and relationships that may be affected by bipolar episodes, educate patients and families about bipolar disorders, etc.