BONE PALM 750

this disorder is characterized by GOF mutation in FGFR3 which produces an exacerbated inhibition of endochondral growth

achondroplasia

this disorder is characterized by a lethal form of gof FGFR3 mutation causing diminished proliferation of chondrocytes and disorganization in the zone of proliferation

thanatophoric dysplasia

this disease is a deficiency in type I collagen causing bones to be brittle, blue sclera, is the most common inherited disorder of connective tissue

osteogenesis imperfecta

this disease is characterized by reduced bone resorption due to deficient osteoclast development or function leading to symmetric skeletal sclerosis

osteopetrosis

how do bones look due to deficient osteoclast activity in osteoporosis?

lack a medullary canal creating a Erlenmeyer flask deformity and the bone tends to be woven

this disease is characterized by impaired mineralization of bone matrix due to vitamin D problems

rickets and osteomalacia

this disease is characterized by a disorder of increased by structurally unsound bone mass, has a predisposition for osteosarcoma, mosaic pattern of lamellar bone deposition with a jigsaw like pattern of cementum lines, and can cause leontiasis osier of the face

paget disease

this disease of hyperparathyroidism is a combo of increased bone cell activity, peritrabecular fibrosis and cystic brown tumors

osteitis fibrosa cystica (Von Recklinghausen disease)

this pattern is shown when osteoclasts tunnel and dissect along trabeculae in hyperparathyroidism

dissecting osteitis

this bone lesion is less than 2 cm in diameter and presents as nocturnal pain which can be relieved with NSAIDs

osteoid osteoma

this bone lesion is > 2 cm and cannot be believed by NSAIDs, and frequently involves the spine rather than tibia and femur

osteoblastoma

the most common primary malignant tumor of bone, Codman triangle, RB mutation increased risk, and formation of bone by malignant cells is characteristic of what tumor?

osteosarcoma

what other name is osteochondroma known as

exostosis

this benign cartilage capped tumor is connected to skeleton by a bony stalk and is the most common benign bone tumor

osteochondroma

this benign tumor of hyaline cartilage has an enchondromatosis type that can be associated with sarcomatous change and are usually less than 3 cm

chondroma

malignant tumors that produce cartilage, commonly arise in axial skeleton, are slow growing, and can be bulky with a gelatinous/myxoid matrix with a lot of cells are know are

chondrosarcoma

a malignant bone tumor of primitive round cells arising in the medullary cavity of long bones and flat bones of pelvis and producing homer wright rosettes is known as?

Ewing sarcoma

a benign but locally aggressive neoplasm has neoplastic osteoclasts with increased destructive resorption producing a large red brown mass undergoing cystic degeneration with the presence of multiple multinucleate giant cells is known as

giant cell tumor

what is another name for giant cell tumor of bone

osteoclastoma

this bone tumor is characterized by multiloculated blood filled cystic spaces separated by thin white septa

aneurysmal bone cyst

what is the most common form of skeletal maligancy?

metastasis