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What are nutrients?
Substances that are consumed or synthesized in the body and are needed for health and when deficient can cause illnesses and specific diseases (40 essential nutrients)
Macro
Carbohydrates
Proteins
Lipids
Water
Micro
Vitamins
Minerals
What are the characteristics and function of carbohydrates?
Function
Provides energy and makes nonessential nutrients
Glucose is the main essential carbohydrate (monosaccharide)
Help make other nonessential nutrients.
Contain monosaccharides either:
Individually.
Bonded together into linear or branched chains.
Types include:
Sugars — mono- and disaccharides.
Starches — digestible polysaccharides.
Fibers — indigestible polysaccharides.
What are the different types of lipids?
Triaglyerecols
Cholesterol
Lechithin/phosphatidycholine (phospholipids)
What are the characteristics and function of triacylglycerols?
Also called fats and oils.
Made of:
3 fatty acids.
Bonded to glycerol.
Major functions:
Provide energy.
Provide fat-soluble vitamins.
Help make other nonessential nutrients.
Fatty acids can be:
Saturated.
Unsaturated.
Cis-monounsaturated.
Cis-polyunsaturated.
Trans fatty acids.
Essential fatty acids include:
Linoleic acid.
Alpha-linolenic acid.
What are the characteristics and function of cholesterol?
Cholesterol is a sterol.
It is used by the body to make:
Steroids.
Bile acids.
Vitamin D
What are the characteristics and function of lecithin/phosphatidylcholine?
A type of phospholipid.
Provides choline.
Helps make:
Cell membranes.
Mitochondrial membranes.
Myelin.
Has a structure similar to fats.
What are proteins made of and what are their major functions?
Made of different amino acids bonded together.
Can form:
Single linear chains.
Multiple linear chains.
Supply 9–10 essential amino acids needed to make body proteins.
Body proteins are important for:
Muscle.
Bone.
Skin.
Hormones.
Transport.
Proteins can also provide:
Energy.
Nitrogen.
Sulfur.
These materials can be used to make nonessential amino acids and other compounds
What are vitamins and what are their main characteristics?
Participate in many chemical reactions, including metabolism.
Do not provide energy.
All vitamins are essential.
Water-soluble vitamins:
B-complex vitamins.
Thiamin
Riboflavin
Niacin
Panthenic acid
B6
Biotin
Folate
B12
Vitamin C.
Fat-soluble vitamins:
Vitamin A.
Vitamin D.
Vitamin E.
Vitamin K.
What is the difference between major and trace minerals?
Minerals are inorganic compounds involved in:
Chemical reactions.
Metabolism.
Building body tissues.
Electrolyte functions.
Major minerals:
Required in larger amounts, >300 mg/day.
Sodium.
Potassium.
Chloride.
Calcium.
Magnesium.
Phosphorus.
Trace minerals:
Required in smaller amounts, <100 mg/day.
Iron.
Zinc.
Copper.
Fluoride.
Iodine.
Chromium.
Selenium
Why is water important?
Considered the most important essential nutrient.
Required in the largest quantity each day.
Major functions:
Lubrication.
Solvent formation.
Fluid production.
Regulation of body temperature.
What are phytochemicals and zoochemicals?
What is a Calorie?
A small calorie is the amount of heat required to raise:
1 gram of water.
By 1°C.
Food labels use a large Calorie, which is a kilocalorie.
1 Calorie = 1 kcal = 1,000 small calories.
1 kcal = 4.18 kJ.
How many Calories are provided by each energy-containing substance?
Carbohydrate:
4 kcal/g.
Protein:
4 kcal/g.
Fat:
9 kcal/g.
Alcohol:
7 kcal/g.
How does the body use food energy?
Converts food energy into:
Chemical energy.
Mechanical energy.
Heat.
Energy can be used to:
Build or synthesize new substances.
Perform muscular movement.
Promote nerve transmission.
Maintain ion and electrolyte balance.
Maintain acid/base balance.
What is the difference between hunger and appetite?
Hunger:
Physiological need for food.
Examples include:
Low blood sugar.
Grumbling stomach.
Appetite:
Psychological desire to eat.
Driven largely by the senses.
Food intake is also influenced by:
Social/cultural factors.
Psychological needs.
Health.
Convenience and availability.
Cost.
What are the five elements of a healthy diet?
Adequacy
Consume enough essential nutrients over time.
Balance
Consume the proper proportion of each nutrient.
Calorie control
Choose foods higher in nutrients and lower in Calories.
Moderation
Practice portion control.
Variety
Eat different types of foods within each food group
What is optimal nutrition?
Consuming the appropriate amount of:
Calories.
Essential nutrients.
Helps achieve:
Maximum health benefits.
Proper body weight.
Healthy aging.
What is malnutrition?
An unhealthy nutritional state involving inadequate or excessive nutrition.
Undernutrition:
Low Calorie or essential nutrient intake.
Can result in:
Subclinical deficiency.
Clinical deficiency.
Overnutrition:
Excess Calorie or nutrient intake.
Can result in:
Toxicities.
Overweight.
Obesity.
What does a nutritional assessment include?
Anthropometric assessment.
Biochemical assessment.
Clinical assessment.
Dietary assessment.
Environmental assessment.
Family and personal medical history.
What warning signs should you look for when evaluating nutrition claims?
Only advantages of a product are discussed.
Claims of a new or “secret” breakthrough.
Claims that something can “cure” a disease.
Claims that sound too good to be true.
Extreme bias against the medical community.
Also examine:
Scientific credentials of the source.
Research supporting the claim.
Study size.
Study duration.
Type of study.
What does the Dietary Supplement Health and Education Act (DSHEA) of 1994 establish?
Classifies supplements as foods rather than drugs.
Supplements do not require FDA approval or the same rigorous regulation as drugs before being sold.
The slides state that the FDA must demonstrate a safety problem rather than the company first proving the product safe.
Supplements do not have to be proven effective for preventing or treating disease simply to be sold if considered reasonably safe with a history of use.
What are the Dietary Reference Intakes (DRIs)?
Nutrition recommendations made by the Food and Nutrition Board.
The slides list five standards:
EAR (estimated average requirements)
RDA (recommended dietary allowances
AI (Adequate intakes)
UL (Tolerable upper intake levels)
EER (Estimated energy requirements)
Used for average daily nutrient and energy consumption.
Why do DRIs differ among people?
DRIs differ according to life stage.
Factors include:
Age.
Gender after age 9.
Pregnancy.
Lactation.
Intended for healthy people.
They are not designed for people who are malnourished or have certain health conditions.
What is an EAR?
Estimated Average Requirement.
Established for 16 essential nutrients that have:
Functional biomarkers.
Strong research.
Represents an average requirement.
Meets the nutrient needs of approximately 50% of the healthy population.
What is an RDA?
Recommended Dietary Allowance.
Calculated from the EAR.
Slide formula:
EAR × 1.2 = RDA.
Meets the needs of approximately:
97–98% of the healthy population.
Intended to help prevent:
Nutrient deficiencies.
Chronic diseases
What is an AI?
Adequate Intake.
Used for 23 other essential nutrients for which an RDA cannot be calculated.
Based more on an estimate than a precise calculation.
Usually set between what would be the RDA and UL.
What is a UL?
Tolerable Upper Intake Level.
Maximum daily intake for nutrients that can show toxicity.
Includes intake from:
Foods.
Supplements.
Medications.
Going above the UL increases the risk of adverse effects.
What is the EER?
Estimated Energy Requirement.
Estimates how many Calories a healthy person should consume per day.
Goal:
Promote a healthy body weight.
What are the AMDRs for carbohydrates, fat, and protein?
AMDR = Acceptable Macronutrient Distribution Range.
Expressed as a percentage of total Calories.
Carbohydrate:
45–65%.
Fat:
20–35%.
Protein:
10–35%.
Intended to help reduce chronic disease risk.
How should DRIs be used?
Intended for:
Diet development.
Diet planning.
Large population groups such as schools and the military.
Individuals should aim to meet their DRI over time.
Intake should not exceed the UL.
Not appropriate for:
Malnourished individuals.
Individuals with certain health conditions.
What makes a food nutrient dense?
Compare its contribution to nutrient needs with its contribution to Calorie needs.
Steps:
Divide the amount of a nutrient per serving by its DRI.
Divide Calories per serving by the Calorie DRI.
Compare the results.
Nutrient dense if the food contributes proportionally more nutrients than Calories for multiple nutrients.
What does energy density mean?
Refers to the amount of Calories per gram of food.
High energy density:
4 Calories/g.
Examples:
Ice cream.
Potato chips.
Nuts.
Bacon.
Avocados.
Low energy density:
<1.5 Calories/g.
Examples:
Green leafy vegetables.
Berries.
Citrus fruits.
Raw carrots.
Vegetable soup.
Skim milk.
What are empty-Calorie or junk foods?
Usually:
High in added sugar and/or fat.
May contain alcohol.
Have few, if any, micronutrients.
Examples:
Sugared soft drinks.
Chips.
Cookies.
Candy.
Beer/mixed drinks.
What is the difference between processed and ultra-processed foods?
Processed foods:
Combine minimal ingredients.
May contain salt, sugar, or oil for preservation/cooking.
Examples:
Canned vegetables.
Cheese.
Fresh bread.
Salted nuts.
Ultra-processed foods:
Formulations made with industrial ingredients and often additives.
Designed for convenience and high palatability.
Little whole food may remain.
Examples:
Soda.
Packaged chips/cookies.
Candy.
Sugary cereal.
Fast food.
Many frozen meals.
Processed meats.
What are Daily Values (DVs)?
Generic nutrition standards developed by the FDA.
Used on food labels.
Apply to most people over age 4.
Exception:
Pregnancy.
Lactation.
Based on:
RDIs.
DRVs.
What is the difference between RDIs and DRVs?
RDIs:
Used for most vitamins and minerals except sodium.
Often use the highest RDA or AI value.
DRVs:
Based on consuming 2000 calories/day
Fat is set at 30% of cals
65g/day
saturated is set for 10% = 20g/day
Calories is set at 60%
300g/day
Fiber is set at 25g/day
Cholesterol is set at 300mg/day
Sodium (2400 mg)
Used for:
Calories.
Carbohydrates.
Fiber.
Total fat.
Saturated fat.
Cholesterol.
Sodium.
What information must appear on food labels?
Product name.
Manufacturer name and address.
Total weight.
Ingredients:
Listed in descending order by weight.
Common allergens.
Nutrition Facts information.
What nutrients are listed on the Nutrition Facts Panel?
Total Calories.
Total fat.
Saturated fat.
Trans fat.
Cholesterol.
Sodium.
Total carbohydrates.
Fiber.
Sugar.
Added sugar.
Protein.
Vitamin D.
Potassium.
Calcium.
Iron.
What are the three major types of front food-label claims?
Nutrient claims:
Example: “low in fat.”
Closely regulated by the FDA.
Health claims:
Connect a dietary pattern or nutrient with disease risk.
Closely regulated by FDA.
Structure/function claims:
Example: “supports heart health.”
Not FDA approved.
Must be accurate.
Manufacturer is responsible for accuracy.
Dietary Guidelines for Americans
Balance calorie intake to manage risk of chronic diseases and body weight
FDA encourages higher intakes of whole, nutrient dense foods
Prioritize proteins
Dairy products
Green leafy vegetables
Fruits
Healthy fats and oils
Whole grain products
FDA discourages high intakes of:
highly processed and ultra processed foods
refined grains
added sugars
sodium/salt
unhealthy fats (saturated and trans)
Soda, fruit juices, and alcohol
Chemical additives
What is the difference between enriched and fortified foods?
Enriched:
Certain micronutrients are added back to refined grains.
Fortified:
Nutrients are added:
At higher-than-normal amounts.
Or when they are not naturally present in the food
What are the major functions of the gastrointestinal tract?
Regulates appetite.
Digests food.
Absorbs nutrients.
Excretes waste.
Plays an important role in immunity by:
Acting as a physical barrier.
Producing immune components.
Housing the gut microbiome.
Controlled by:
Hormones.
Nervous system.
What organs make up the GI tract?
Mouth and salivary glands.
Esophagus.
Stomach.
Small intestine.
Large intestine.
Accessory organs:
Liver.
Gallbladder.
Pancreas.
What are the functions of the GI tract?
Helps regulate appetite
Digests food, absorbs nutrients, and excretes waste
Helps in immunity
Acts as a physical barrier
Produces immune components
Houses bacteria
Controlled by hormones and the nervous system
What are the four layers of the GI tract wall?
Mucosa
Innermost layer.
Contains various cell types.
Submucosa
Connective tissue.
Muscle
Thickest layer.
Circular and longitudinal muscles.
Serosa
Outermost connective tissue layer.
What is peristalsis?
Movement that propels food through the GI tract.
Consists of coordinated waves of:
Muscle contraction.
Muscle relaxation.
Food is simultaneously mixed with digestive secretions.
Segmentation also occurs but only in the small intestine.
What happens to food in the mouth?
Chewing:
Physically breaks food apart.
Increases its surface area.
Mixes food with saliva.
Makes swallowing easier.
Saliva contains:
Lysozymes → kill bacteria.
Mucus → moistens food.
Salivary alpha-amylase → begins starch digestion.
Electrolytes → enhance flavor
What is the function of the esophagus?
Transfers food from the mouth to the stomach.
Swallowing moves the bolus:
From the mouth.
Through the throat.
Into the esophagus.
The epiglottis:
Prevents food from entering the trachea.
Helps prevent choking during swallowing.
What is the function of the lower esophageal sphincter (LES)?
Allows the food bolus to enter the stomach.
Helps prevent:
Food.
Stomach acid.
From backing up into the esophagus.
What happens to food in the stomach?
Stomach serves as a:
Holding tank.
Mixing tank.
Food bolus mixes with stomach secretions.
This mixture becomes chyme.
Stomach volume:
About 50 mL when empty.
About 1.5 L when full.
What are the functions of hydrochloric acid (HCl) in the stomach?
Increases stomach acidity.
Denatures proteins.
Kills bacteria.
Dissolves and ionizes minerals.
Releases lipids bound to proteins.
Converts:
Pepsinogen → pepsin.
What is pepsin?
Digestive enzyme in the stomach.
Begins protein digestion.
Produced initially as pepsinogen.
HCl converts pepsinogen into active pepsin
What is gastrin?
Hormone associated with stomach digestion.
Promotes secretion of:
HCl.
Pepsinogen.
Why is mucus important in the stomach?
Protects the stomach lining from:
HCl.
Pepsin.
Mucus production relies on prostaglandin synthesis.
Chronic oral use of certain NSAIDs and anti-inflammatory steroids can:
Inhibit prostaglandin production.
Reduce mucus production.
Contribute to inflammation and ulceration.
What is intrinsic factor?
A protein produced in the stomach.
Needed for the absorption of vitamin B12.
What is the function of the pyloric sphincter?
Controls the movement of chyme:
From the stomach.
Into the small intestine.
What is GIP and what does it do?
GIP = glucose-dependent insulinotropic peptide.
Slows the movement of food.
Helps keep the stomach full longer.
The slide notes this is partly controlled by increased:
Fiber consumption.
Protein consumption.
What are the three sections of the small intestine?
Duodenum
Upper portion.
Jejunum
Middle portion.
Ileum
Lower portion.
Most digestion and absorption occurs in the upper half of the small intestine.
What are villi and why are they important?
Villi form hills and valleys along the mucosa of the small intestine.
They are lined with different cells:
Goblet cells
Produce mucus.
Endocrine cells
Produce hormones.
Enterocytes
Produce digestive enzymes.
Absorb most nutrients.
Enterocytes contain a brush border of microvilli.
The villi/microvilli structure increases the surface available for absorption.
What does the liver do during digestion?
Produces bile.
Bile contains:
Bile salts.
Cholesterol.
Phospholipids.
Mostly water.
Bile aids in:
Fat digestion.
Fat absorption.
What does the gallbladder do?
Stores bile.
Releases bile during eating.
The slide associates this process with cholecystokinin (CCK).
What does the pancreas contribute to digestion?
Produces and secretes:
Sodium bicarbonate.
Digestive enzymes.
Digestive enzymes include:
Lipases.
Proteases.
Alpha-amylase.
The slide also associates pancreatic secretion with secretin.
What structures make up the large intestine?
Ileocecal valve.
Colon:
Cecum.
Ascending colon.
Transverse colon.
Descending colon.
Sigmoid colon.
Rectum.
Anus.
Undigested or unabsorbed material from chyme passes through the ileocecal valve into the large intestine
What are the major functions of the large intestine?
Absorbs:
Water.
Electrolytes.
Some minerals.
Responsible for:
Formation of feces.
Storage of feces.
Expulsion of feces.
Houses the majority of GI-tract bacteria.
What are the functions of beneficial bacteria in the GI tract?
Help control the growth of pathogenic bacteria.
Synthesize:
Vitamin K.
Biotin.
Help ferment undigested carbohydrates.
Fermentation produces:
Short-chain/volatile fatty acids.
Energy.
What are probiotics?
Live bacteria found in:
Foods.
Supplements.
Examples listed in the slides include:
Yogurt.
Cheeses
What are prebiotics?
Non digestible carbohydrates in food that promote the growth of beneficial bacteria
Fiber and resistant starch
Where does most nutrient absorption occur?
Most nutrient absorption occurs in the small intestine (SI).
Absorption primarily occurs through enterocytes.
A small amount of absorption also occurs in:
Stomach.
Large intestine
What are the three major methods of nutrient absorption?
Passive diffusion
Does not require energy.
Used for:
Lipids.
Fat-soluble vitamins.
Facilitated diffusion
Requires cell membrane proteins.
Used for:
Some amino acids.
Fructose.
Water-soluble vitamins.
Active transport
Requires:
Cell membrane proteins.
Energy.
Used for:
Glucose.
Galactose.
Some amino acids.
Minerals.
After nutrients are absorbed, how are they transported through the body?
Nutrients absorbed by GI tract cells enter either:
Cardiovascular system.
Lymphatic system.
Which system is used depends on the solubility of the nutrient.
How are water-soluble nutrients transported?
Absorbed directly into the capillary beds of the GI tract.
Transported to the liver through the hepatic portal vein.
The liver can then:
Metabolize some nutrients.
Store some nutrients.
Send nutrients into the systemic bloodstream.
Nutrients in systemic circulation can then be used by cells throughout the body
How are fat-soluble nutrients transported?
Fat-soluble nutrients include:
Lipids.
Fat-soluble vitamins.
They are absorbed into the lacteals within the villi.
They travel through the lymphatic system to the thoracic duct.
The thoracic duct leads into the:
Left subclavian vein.
Vena cava.
Systemic bloodstream.
This route initially bypasses the liver.
What is the major difference between the transport of water-soluble and fat-soluble nutrients?
Water-soluble nutrients:
Enter blood capillaries.
Travel through the hepatic portal vein.
Reach the liver first.
Fat-soluble nutrients:
Enter lacteals.
Travel through the lymphatic system.
Enter systemic circulation.
Initially bypass the liver.
How is the GI tract regulated?
Regulation involves several processes.
Nervous system:
Stimulates appetite.
Causes stomach growling.
Stimulates saliva secretion.
These responses may occur because of:
Senses, such as smell.
Nutrient levels in the blood, such as low blood sugar.
Hormones also play major roles.
Which appetite hormones should you remember?
Appetite ON:
Ghrelin → stomach.
Neuropeptide Y → brain.
Appetite OFF:
Leptin → adipose tissue.
GLP-1 → intestines.
Secretions OFF in stomach and pancrease:
Somatostatin
What is the difference between heartburn and GERD?
Heartburn
Acute condition.
GERD
Gastroesophageal reflux disease.
Chronic condition.
Both involve the backward flow of stomach contents, including HCl, into:
Esophagus.
Throat.
What damage can chronic GERD cause?
Backflow of stomach acid can cause:
Inflammation.
Ulceration.
According to the lecture, it can also contribute to cancer involving:
Esophagus.
Throat.
Voice box.
What factors can contribute to heartburn and GERD?
Foods/beverages listed in the lecture:
Citrus juices.
Sodas.
Coffee.
Chocolate.
Deep-fried foods.
Spicy foods.
Alcohol.
Other factors:
Hiatal hernia.
Large meals/overeating.
Tight-fitting pants around the waist.
Lying down after eating.
How are heartburn and GERD treated?
Medications may include:
Antacids.
Acid inhibitors.
Acid blockers.
What are gastritis and peptic ulcers associated with?
Oversecretion of HCl.
Increased activation of pepsin, particularly with an empty stomach.
Can lead to:
Inflammation.
Ulceration of the stomach.
The lecture also notes possible progression to stomach cancer.
What can cause gastritis and peptic ulcers?
Same factors listed for GERD, plus:
H. pylori.
NSAID use.
Oral steroid use.
Mental stress.
Smoking.
Chronically chewing gum on an empty stomach.
How are gastritis and peptic ulcers treated?
Depending on the cause:
Antibiotics.
Discontinuation of NSAIDs or oral steroids.
Acid inhibitors.
Acid blockers.
What is metabolic dysfunction-associated steatotic liver disease (MASLD)?
Occurs when liver cells store excess fat.
Excess fat can lead to:
Liver swelling.
Inflammation.
Scarring.
Cirrhosis.
Liver failure.
The lecture associates it mostly with higher intake of:
Sugar.
Refined carbohydrates.
What is MASH?
Metabolic dysfunction-associated steatohepatitis.
Refers to the condition when inflammation is present with MASLD.
Who most commonly develops MASLD according to the lecture?
Mostly adults with:
Obesity.
Type II diabetes.
Insulin resistance.
What are symptoms of MASLD?
Fatigue.
Nausea.
Poor appetite.
Weight loss.
Jaundice.
Diffuse pain under the right rib cage, where the liver is located.
How is MASLD treated according to the lecture?
Gradual weight loss.
Reduce:
Refined carbohydrates.
Sugar.
Foods listed for reduction include:
Bread.
Rice.
Pasta.
Potatoes.
Soda.
Candy.
Fruit and fruit juices.
What is irritable bowel syndrome (IBS)?
A lower GI tract disorder.
Symptoms include:
Abdominal pain/cramping.
Stomach bloating.
Flatulence.
Diarrhea.
The lecture states it is most commonly seen in young females.
What foods may trigger IBS according to the lecture?
High-salt foods.
Spicy foods.
High-fat foods.
Cruciferous vegetables.
The lecture also lists:
“Cafeteria or restaurant dining.”
How is IBS treated according to the lecture?
Avoid trigger foods.
Exercise regularly.
Anti-diarrheal medications.
What is inflammatory bowel disease (IBD)?
Chronic inflammation involving the:
Small intestine.
Large intestine.
Includes:
Ulcerative colitis.
Crohn's disease.
What are symptoms of IBD?
Persistent diarrhea.
Abdominal pain.
Rectal bleeding/bloody stools.
Weight loss.
What causes IBD according to the lecture?
Associated with:
Autoimmune disorder.
Genetics.
How is IBD treated?
Surgery to remove damaged areas.
Oral steroids.
Immunomodulators.
What are the two major forms of IBD?
Ulcerative colitis.
Crohn's disease.
What is celiac disease according to the lecture?
Described in the lecture as an allergic reaction to gluten.
Gluten-containing foods/grains listed include:
Wheat.
Rye.
Barley.
Couscous.
Semolina
How common is celiac disease according to the lecture?
Approximately 1 in 133 people are affected.
The lecture states that many others may have:
Gluten intolerance.
Gluten sensitivity.
Many cases may be undiagnosed.
How does celiac disease affect the small intestine?
Causes the small intestine to become:
Inflamed.
Swollen.
This can interfere with nutrient absorption.
As a result, multiple nutrient deficiencies can develop.
What is the dietary treatment for celiac disease?
Follow a gluten-free diet for life.
Alternatives listed in the lecture include:
Corn.
Rice.
Oats.
Quinoa.
Buckwheat.
What are food intolerances?
The lecture gives examples such as:
Lactose intolerance.
Gluten intolerance.
Symptoms can include:
Stomach ache.
Bloating.
Gas.
Diarrhea.
Management:
Avoid foods that cause problems.