Reversible Growth Disorder IV

Anaplasia

Reversion of cells to a more primitive and less differentiated type

dedifferentiation and undifferentiation

Anaplasia is synonymous with

structural, functional

In anaplasia, cells lose _____ and _____ characteristics

dysplasia

Anaplasia resembles ______ morphologically

progenitor or ancestral

Anaplasia is characterized from simple going backward (instead of mature wbc, you see _______cells)

1. great pleomorphism

2. cells becoming very large (giant)

3. hyperchromatic nuclei

4. increased nucleocytoplasmic ratio

5. increased mitotic activity

Characteristics of anaplasia under microscope

euplasia

Normal growth

proplasia

slight increase or stimulation of growth

retroplasia

decreased growth activity through injury or aging

anaplasia

loss of differentiation of cells and tissues

irreversible

Anaplasia is also characterized as _______, a precursor to neoplasia