Inflammatory Bowel Disease (IBD) Practice Flashcards

Fill-in-the-blank practice flashcards covering the definition, genetics, epidemiology, anatomical distribution, clinical features, extraintestinal manifestations, scoring systems, and treatments of Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease).

Inflammatory bowel diseases (IBD) consist of two distinct entities: ulcerative colitis and __________ disease.

Crohn's

According to the pathophysiological diagram, the four key factors contributing to IBD are immunology, microflora, environment, and __________.

genetics

In twin studies of IBD, the concordance rate among monozygotic twins is __________%.

36

The frequency of CARD15-NOD-2 gene mutations in patients with Crohn's disease is __________%.

29

Tobacco smoking acts as a __________ factor in ulcerative colitis.

protective

Tobacco smoking __________ the risk of Crohn's disease and its complications.

increases

Ulcerative colitis is a non-transmural inflammatory disease limited to the __________.

colon

In ulcerative colitis, the __________ and the rest of the upper gastrointestinal tract are always spared.

anus

Crohn's disease is a __________ inflammatory disease that can affect any part of the digestive tract from mouth to anus.

transmural

The sex ratio (M/F) for Crohn's disease is __________.

1.4

The most frequent anatomical location of Crohn's disease is the __________ region, accounting for 30 to 50% of cases.

ileocolic

In the Montreal classification diagram for Crohn's disease, L1 corresponds to involvement of the terminal __________.

ileum

Microscopically, the diagnostic hallmark lesion found in Crohn's disease is the epithelioid and giant cell __________.

granuloma

In stenotic forms of Crohn's disease, postprandial abdominal pain relieved abruptly by hydro-aeric gurgling is known as the __________ syndrome.

König

Primary sclerosing cholangitis is an extraintestinal manifestation more frequently associated with __________ than with Crohn's disease.

ulcerative colitis

Anoperineal manifestations such as fissures, fistulas, and abscesses are revealing in __________% of Crohn's disease cases.

25

Endoscopic severity of ulcerative colitis is classified using the __________ score.

Mayo

Clinical activity in Crohn's disease is evaluated using the Best score, also called the __________.

CDAI

A Best Score (CDAI) value of less than __________ indicates quiescent disease.

150

According to the Truelove and Witts score, severe ulcerative colitis is defined by __________ or more bloody stools per 24 hours.

6

In ulcerative colitis, extension of inflammation to the entire colon up to the cecum is termed a __________.

pancolitis

The preferred surgical intervention in Crohn's disease localized to the terminal ileum and cecum is an __________ resection.

ileocecal

After the initial flare of ulcerative colitis, __________% of patients will experience at least one relapse within 20 years.

95

Long-term complications of ulcerative colitis include dysplasia, which carries a high risk of colorectal __________.

cancer