7 - Wound Healing (Absite 2024)

1. Hemostasis and inflammation

2. Proliferation

3. Maturation and remodeling

The phases of healing are:

1.

2.

3.

4 to 12

The proliferative phase is the second phase of wound healing and roughly spans days _____

Platelet-derived growth factor

What is the strongest chemotactic factor for fibroblasts?

Matrix metalloproteinases

During the maturation of scar tissue, collagen is broken down by ______

Collagen type III; collagen type I

During early wound healing, fibronectin and collagen type _____ constitute the matrix while collagen type ____ constitutes the final matrix

FBN-1 gene mutation

This encodes for fibrillin

Patients with Marfan syndrome are associated with what genetic defect?

Submucosa

Important to remember for surgical repair of the GI tract

The ____ is the layer of the intestine that imparts the greatest tensile strength and greatest suture-holding capacity

Local tissue infection

The major cause of impaired wound healing is ____

Vitamin A

Vitamin C also shows benefits to wound healing

Vitamin ___ supplementation has shown to be beneficial to wound healing through increasing collagen production and epidermal growth factor receptors

Type III

It is the most prominent during the repair process

Collagen type _____ is the most important to wound healing

Over­ turned wound edges

This would be confirmed by biopsy

Malignant wounds are differentiated clini­cally from nonmalignant wounds by the presence of ______

Excision with adjuvant therapy

The treatment of choice for keloids is _____

Intraabdominal adhesions

The most common cause of small bowel obstruction are ____

Platelet-derived growth factor (PDGF)

____ is the only approved growth factor for treatment of diabetic foot ulcers