Vaughan Williams Antiarrhythmic Drug Classification

A set of vocabulary flashcards detailing the Vaughan Williams classification of antiarrhythmic drugs, including their class names, specific drug examples, primary mechanisms of action, and predominant physiological effects as listed in the provided notes.

Class IA Antiarrhythmic Drugs

Procainamide, Disopyramide, and Quinidine.

Class IA Mechanism and Predominant Actions

Na+ channel blockade resulting in $\downarrow$ AP conduction velocity and $\uparrow$ AP duration.

Class IB Antiarrhythmic Drugs

Lidocaine and Mexiletine.

Class IB Mechanism and Predominant Actions

Na+ channel blockade resulting in unchanged AP conduction velocity and $\downarrow$ AP duration.

Class IC Antiarrhythmic Drugs

Flecainide and Propafenone.

Class IC Mechanism and Predominant Actions

Na+ channel blockade resulting in $\downarrow$ AP conduction velocity and unchanged AP duration.

Class II Antiarrhythmic Drugs

Metoprolol, Atenolol, and Esmolol.

Class II Mechanism and Predominant Actions

$\beta$-Blockade resulting in $\downarrow$ SA node firing rate, $\downarrow$ AV node conduction rate, and $\downarrow$ Atrial & ventricular automaticity.

Class III Antiarrhythmic Drugs

Amiodarone, Dronedarone, Dofetilide, and Sotalol.

Class III Mechanism and Predominant Actions

K+ channel blockade resulting in unchanged AP conduction velocity and $\uparrow$ AP duration.

Class IV Antiarrhythmic Drugs

Verapamil and Diltiazem.

Class IV Mechanism and Predominant Actions

Ca2+ channel blockade resulting in $\downarrow$ SA node firing rate and $\downarrow$ AV node conduction rate.