raynauds, myastenia gravis, sjorgens, psoriasis (NAPLEX)

Raynauds TX (1)

Nifedipine

What drugs can worsen raynauds? (4)

• Beta-blockers

• Sympathomimetics: amphetamine, pseudophed, cocaine

• Bleomycin

• Cisplatin

What is myasthenia gravis?

Autoimmune condition that attacks the connections between nerves & muscles

• Typically the Acetycholine receptors

Myasthenia gravis symptoms (4)

• Eye/vision changes

• Drooping eyelids

• Difficulty chewing or swallowing

• Jaw or neck tightness

Myasthenia gravis TX (1)

• Pyridostigmine - cholinesterase inhibitor that blocks the breakdown of acetycholine by acetycholinesterases

Pyridostigmine adverse effects

• Cholinergic effects: symptoms of excess ACh can occur like salivation, lacrimation, urination, and diarrhea

What is sjogren's syndrome?

Dry eyes and dry mouth

• Complications: cavities, corneal ulcerations, chronic oral infections

Dry eyes TX (3)

• OTC artifical tears like systane

• Cyclosporine (Restasis)

• Lifitegrast

Cyclosporine eye drops brand name

Restasis

What is the preservative in OTC eye drops?

Benzalkonium chloride

Dry mouth TX (4)

• Sugar free gum with xylitol or lozenges

• Daily rinses with antimicrobial mouthwash

• Pilocarpine (oral muscarinic agonist)

• Cevimeline (oral muscarinic agonist)

Pilocarpine & cevimeline contraindications (2)

• Uncontrolled asthma

• Narrow angle glaucoma

Plaque psoriasis appearance

Raised, red patches covered with silvery white buildup

What is the nondrug Tx for psoriasis?

UV light that causes activated T cells in the skin to die

• UVB phototherapy

Topical psoriasis TX (2)

• Steroids

• Coal tar products

Systemic psoriasis TX (3)

• Acitretin for severe cases

• Apremilast

• Interleukin receptor antagonists like risankizumab (skyrizi)

Calcipotriene is a derm drug that is used for ______

psoriasis

Which of the following contains gluten? SATA

A. Oats

B. Wheat

C. Barley

D. Rye

E. Rice

B, C, D

Exacerbation of celiac disease can include which of the following symptoms? SATA

A. Diarrhea

B. Heartburn

C. Weight loss

D. Weight gain

E. Abdominal pain

F. Bloating

A, C, E, F