PC2 MOD 4.1.7

SARS COV 2 structure

spike glycoprotein-

M protein

envelope glycoprotein

covid variants

viruses evolve over time undergo changes acquiring mutations as they spread & replicate. MORE ROUNDS OF REPLICATION= GREATER CHANCE OF MUTATION

covid transmission

airborne, droplets, direct/indirect contact

covid early pandemic

primarily affect lower respiratory system

covid 19 current presentation

upper respiratory symptoms predominate

cold &) flu like symptoms

covid vaccines

CDC recommends vaccines for those greater than or equal to 6 months

mRNA vaccine= serious AEs like anaphylaxis & myocarditis/pericarditis

covid adjuvant purpose

adjuvant= used to boost immune responses… a smaller dose of spike protein can be utilized w/out compromising effectiveness

paxlovid preferred tx for covid

BAD TASTE

RITONAVIR HAS DDI

molpunavir tx for covid

cons= approval was NARROW

SAFETY CONCERNS= BIRTH DEFECTS OR LONG TERM EFFECTS, MAY CAUSE CANCER

hospitalized adults COVID 19 tx

DEXAMETHASONE FOUNDATIONAL TREATMENT

DO NOT GIVE DEXAMETHASONE to pts who DO NOT REQUIRE supplemental O2