ch 4 factors that decrease platelet count

decreased platelet count may result from

diminished or defective platelet production

increased peripheral destruction of platelets

sequestration

blood loss

congenital diminished or defective platelet production

Wiskott-Aldrich syndrome

maternal ingestion of thiazides

neonatal rubella

acquired diminished or defective platelet production

aplastic anemia

marrow infiltration- acute and chronic leukemia, tumor

nutritional deficiency B12, folic acid

myelosuppressive agents

drugs that directly influence platelet production (thiazides, alcohol, hormones)

radiation

viral infections- measles, dengue

congenital increased peripheral destruction

nonimmune - prematurity, erythroblastosis fetalis, infection

immune - drug-induced esp w quinine and quinidine, post-transfusion purpura, acute and chronic idiopathic thrombocytopenic purpura, sepsis, alcohol

acquired increased peripheral destruction of platelets

invasive lines or devices

ventricular assist devices

intra-aortic balloon pump

cardiopulmonary bypass

artificial hearts and prosthetic valves

heparin administration

sequestration

hypersplenism

hypothermia

blood loss

hemorrhage

bleeding