CD Markers and Hematologic Malignancy Panels

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Vocabulary flashcards based on the provided lecture notes on CD markers and hematologic malignancy panels.

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52 Terms

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CD10

Early B cells, Germinal center

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CD19

All B cells (except plasma cells)

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CD20

Mature B cells

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CD21

Complement receptor

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CD22

Regulatory B cell function

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CD27

Memory B cells

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CD34

Stem cell, early marker

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CD38++

Plasma cells

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CD79a/b

BCR signaling complex

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CD138

Plasma cells

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PAX5

B-lineage TF, absent in plasma cells

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CD1a

Cortical thymocytes (DP)

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CD2

Early T cells

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CD3

All mature T cells (surface), cytoplasmic in early T cells

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CD4

Helper T cells

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CD5

Pan-T; also in CLL, mantle cell lymphoma

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CD7

Early T cells

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CD8

Cytotoxic T cells

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CD25

Treg marker

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CD28

Costimulation (binds B7)

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CD45RA/RO

Naive/memory phenotyping

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CD69

Early activation

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CTLA-4, PD-1

Inhibitory checkpoints

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FOXP3

Treg TF (not CD but essential)

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CD16, CD56

NK core markers

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CD57

Subset marker

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CD13, CD33

Myeloid markers

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CD14, CD64

Monocytes

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CD15, CD66b

Granulocytes

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HLA-DR

Present in many blasts

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MPO

Myeloid lineage

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CD34+, CD19+, CD10+, TdT+

Key CD markers for Pro-B cells

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CD19+, CD10+, TdT+, cytoplasmic Ig

Key CD markers for Pre-B cells

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CD19+, CD20+, CD21+, surface IgM

Key CD markers for Immature B cells

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CD19+, CD20+, CD21+, IgM+, IgD+

Key CD markers for Naive B cells

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CD10+, CD19+, CD20+, BCL6+, sIg+, BCL2+

Key CD markers for Germinal Center B cells

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CD27+, CD19+, CD20+, IgG/A/E

Key CD markers for Memory B cells

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CD38+, CD138+/-, CD19+/-, CD20-

Key CD markers for Plasmablast

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CD38++, CD138++, CD19-, CD20-

Key CD markers for Plasma Cell

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CD28

T cell cant activate without 28

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B7 (CD80/86)

APC ligand for CD28

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CD40L

Helps B cells class switch

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CTLA-4

Competes with CD28

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PD-1

T cell exhaustion

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CD69

Early activation

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CD22

Inhibits BCR signaling

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CD16, CD56

Key NK markers

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CD14, CD64

General monocyte/macrophage marker

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CD68

Phagocytosis marker (macrophage)

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CD163

M2 macrophage marker (anti-inflammatory)

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CD117

Stem cell factor receptor

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TdT

Immature lymphoid cells (esp. ALL)