2 - Hemostasis, Surgical Bleeding, and Transfusion (Absite 2024)

1. Vascular constriction

2. Platelet plug formation

3.Fibrin formation

4. Fibrinolysis

The 4 major physiologic events in the hemostatic process are:

1.

2.

3.

4.

Adenosine diphosphate (ADP) and serotonin

_____ and _____ are the principal mediators in platelet aggregation

von Willebrand factor

This protein binds to GP I/IX/V on the platelet membrane

_______ is required for platelet adherence to injured endothelium

Factor XII --> Factor XI --> Factor IX --> Factor VIII

What are the components of the intrinsic pathway? (in order)

Factor X (Stuart-Prower factor)

What clotting factor is the meeting point of the intrinsic and extrinsic pathway?

Factor XIII

What congenital factor deficiency is associated with delayed bleeding after initial hemostasis?

5-7 days

In a previously unexposed patient, heparin-induced thrombocytopenia manifests as platelet count fall after ____ days

Shock and tissue injury

Acute coagulopathy of trauma is caused by ___ and

____.

Storage pool disease

The most common intrinsic platelet defect is known as ____

7 g/dL

The hemoglobin cut-off for blood transfusion is < ____ g/dL

Human error

Ex. blood drawn for typing from the wrong patient, blood incorrectly cross­ matched in the laboratory, blood units mislabeled in the labo­ratory, blood administered to the wrong patient.

The most common cause for a transfusion reaction is ____

Factor VIII or Factor V

Frozen plasma is required for the transfusion of ______ or ______

Oliguria

Followed by hemoglobinuria

The most common clinical manifestation of a hemolytic transfusion reaction is _____