NUR318 Exam 2 Drugs MOA

SSRIs

decrease reuptake of serotonin which increases the amount of serotonin in brain

SNRIs

decrease reuptake of serotonin and norepinephrine

NDRIs

decrease reuptake of norepinephrine and dopamine

Which is the only antidepressant with dopamine reuptake inhibition as a major mechanism of action?

bupropion

TCAs

block reuptake of norepinephrine and serotonin

MAOIs MOA

block enzymatic breakdown of monoamines thus “leaving” more available for the depressed brain

Non Selective irreversible inhibitors

inhibit both variants of monoamine (A and B)

Selective MAOIs

inhibits only MAO-A

Selegiline inhibits

MAO-B

Lithium inhibits

release of norepinephrine, serotonin, and dopamine

Anticonvulsant valproates

increase the inhibitory role of GABA

Benzodiazepine MOA

enhance GABA effects

Carbamazepine

blocks sodium channels

Lamotrigine

blocks sodium channels and decreases glutamate release

First gen antipsychotics

block dopamine receptors

Second gen antipsychotics

block dopamine and serotonin receptors