Gene Regulation, Protein Production, and Degradation: Transcription in Eukaryotes

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37 Terms

1
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Which eukaryotic RNA polymerase II subunit possesses a flexible C-terminal tail?
Subunit 1
2
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We understand every detail about PIC assembly in eukaryotes.
False
3
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TFIIH is the most complex general transcription factor.
True
4
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The pre-initiation complex refers to:
RNA polymerase II in complex with many general transcription factors
5
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Both prokaryotic and eukaryotic transcription initiation require many initiation factors.
False
6
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Mediator is required for transcription initiation of almost all eukaryotic genes.
True
7
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Unlike prokaryotic RNA polymerase, which possesses additional subunits on top of the core, eukaryotic RNA polymerase does not possess additional subunits.
False
8
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RNA polymerase from archaea, prokaryotes, and eukaryotes, all possess the same multi-subunit core.
True
9
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TFIIA is composed of:
2 subunits
10
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The eukaryotic RNA polymerase core is composed of the following subunits.
2 alphas, beta, beta’, omega
11
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The 24 subunits of Mediator are divided into how many lobes?
3
12
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TFIIE interacts with:
The RNA polymerase II stalk and TFIIF
13
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TFIID is composed of:
\~ 14 subunits divided among 3 lobes
14
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Which GTF(s) possess enzymatic activity?
TFIIH
15
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What causes DNA to bend sharply around the region of the transcription start site?
Binding of TBP to the TATA box
16
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Which RNA eukaryotic RNA polymerase is used to transcribe mRNA?
RNA polymerase II
17
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General transcription factors assemble around the transcription start site.
True
18
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How is RNA polymerase II physically attached to the rest of the PIC upon recruitment?
Binding to the B-ribbion of TFIIB
19
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General transcription factors are recruited by the transcription start site.
False
20
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BREd is located:
Directly adjacent to the TATA box on the downstream side of the TATA box
21
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RNA polymerase II arrives to the PIC in complex with:
TFIIF
22
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Mediator is:
A huge complex and last to join the PIC
23
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RNA polymerase II is composed of:
12 subunits
24
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The RNA polymerase stalk:
Is composed of additional subunits on top of the core subunits
25
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TFIIE is recruited to the PIC before TFIIF.
False
26
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The TATA box is located:
\~ 25 bps upstream of the transcription site
27
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RNA polymerase II is recruited to the transcription start site by binding to nearby promoters.
False
28
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TFIIB is composed of:
1 subunit
29
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TFIIF is composed of:
2 subunits
30
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TBP:
Binds to the TATA box
31
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How many subunits does eukaryotic RNA polymerase II possess?
12
32
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TFIID is the first general transcription factor to be recruited to the area of the transcription start site.
True
33
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TFIIH interacts with:
TFIID, DNA, RNA polymerase II stalk
34
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How many different types of RNA polymerase do eukaryotes possess?
3
35
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TAF1 and TAF7 bind to:
MTE and DPE
36
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Which protein(s) bind to the convex surface of TBP?
TFIIA and TAF1
37
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Before TFIIA is recruited, TBP is held in place within the TFIID complex by:
A flexible region of TAF1