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Elderly
65+
Young old
65-74
Old old
75-84
Very old old
85+
most rapidly growing age group
Adults 85+
Pharmacokinetics
how does drug get in and out of the body
Absorption
LEAST impacted by aging
IM absorption
less muscle therefore less absorption
Topical
less skin hydration therefore less absorption via patches
Anticholingerics
adverse effects like dry eyed, mouth blurred vision. Avoid meds with these sides
Cardio/renal - heart failure
most costly medicare diagnosis in US
Stroke
most feared conditions amongst older adults
Renal elimination
With age means ur kidneys wont work that well hence a decrease CrCl (creatinine clearance)
Pharmacodynamics
Increased receptor sensitivity with benzodiazepines and CNS depressants
Decreased receptor sensitivity for beta adrenergic receptors
Decreased baroreceptor sensitivity