REPRODUCTIVE AGENTS

Premarin Estrogens — Endocrine agent

Premarin PO/Function/Common Use PO — Mimics estrogen (estrone) — Estrogen replacement in menopause

Premarin Adverse Drug Reactions/Special Considerations Increased risks: breast/endometrial cancers; cardiovascular events (stroke, myocardial infarction); blood clots (VTE) — Breast tenderness, headache, nausea — Used only in patients who had a hysterectomy; do not give in pregnancy or with active liver disease

Estradiol Estrace, Climara, Estrogel — Estrogens; Endocrine agent

Estradiol PO/DERM/Function/Common Use PO, DERM — Mimics estrogen (estrone) — Estrogen replacement in menopause

Estradiol Adverse Drug Reactions/Special Considerations Increased risks: breast/endometrial cancers; cardiovascular events (stroke, myocardial infarction); blood clots (VTE) — Breast tenderness, headache, nausea — Used only in patients who had a hysterectomy; do not give in pregnancy or with active liver disease

Ethinyl estradiol-desogestrel Apri, Kariva, Mircette — Oral contraceptive

Ethinyl estradiol-desogestrel PO/Function/Common Use PO — Mimics estrogen (estradiol) and progesterone — Contraception, regulation of menses

Ethinyl estradiol-desogestrel Adverse Drug Reactions/Special Considerations Increased risks: breast/endometrial cancers; cardiovascular events (stroke, myocardial infarction); blood clots (VTE) — Breast tenderness, headache, nausea — Do not give in pregnancy or with active liver disease

Ethinyl estradiol-drospirenone Yaz, Yasmin, Ocella — Oral contraceptive

Ethinyl estradiol-drospirenone PO/Function/Common Use PO — Mimics estrogen (estradiol) and progesterone — Contraception, regulation of menses

Ethinyl estradiol-drospirenone Adverse Drug Reactions/Special Considerations Increased risks: breast/endometrial cancers; cardiovascular events (stroke, myocardial infarction); blood clots (VTE) — Breast tenderness, headache, nausea — Do not give in pregnancy or with active liver disease

Ethinyl estradiol-levonorgestrel Aviane, Alesse — Oral contraceptive

Ethinyl estradiol-levonorgestrel PO/Function/Common Use PO — Mimics estrogen (estradiol) and progesterone — Contraception, regulation of menses

Ethinyl estradiol-levonorgestrel Adverse Drug Reactions/Special Considerations Increased risks: breast/endometrial cancers; cardiovascular events (stroke, myocardial infarction); blood clots (VTE) — Breast tenderness, headache, nausea — Do not give in pregnancy or with active liver disease

Ethinyl estradiol-norethindrone Loestrin, Nortel, Ortho-Novum — Oral contraceptive

Ethinyl estradiol-norethindrone PO/Function/Common Use PO — Mimics estrogen (estradiol) and progesterone — Contraception, regulation of menses

Ethinyl estradiol-norethindrone Adverse Drug Reactions/Special Considerations Increased risks: breast/endometrial cancers; cardiovascular events (stroke, myocardial infarction); blood clots (VTE) — Breast tenderness, headache, nausea — Do not give in pregnancy or with active liver disease

Ethinyl estradiol-norgestimate Ortho Tri-Cyclen, Previfem — Oral contraceptive

Ethinyl estradiol-norgestimate PO/Function/Common Use PO — Mimics estrogen (estradiol) and progesterone — Contraception, regulation of menses

Ethinyl estradiol-norgestimate Adverse Drug Reactions/Special Considerations Increased risks: breast/endometrial cancers; cardiovascular events (stroke, myocardial infarction); blood clots (VTE) — Breast tenderness, headache, nausea — Do not give in pregnancy or with active liver disease

Ethinyl estradiol-etonogestrel NuvaRing, EluRyng — Vaginal contraceptive

Ethinyl estradiol-etonogestrel Vaginal/Function/Common Use Vaginal — Mimics estrogen (estradiol) and progesterone — Contraception, regulation of menses

Ethinyl estradiol-etonogestrel Adverse Drug Reactions/Special Considerations Increased risks: breast/endometrial cancers; cardiovascular events (stroke, myocardial infarction); blood clots (VTE) — Breast tenderness, headache, nausea — Do not give in pregnancy or with active liver disease

Medroxyprogesterone acetate Depo-Provera, Provera — Endocrine agent; Progestin

Medroxyprogesterone acetate SC/IM/Function/Common Use SC, IM — Mimics progesterone — Contraception (IM or SC injection)

Medroxyprogesterone acetate Adverse Drug Reactions/Special Considerations Increased risk of osteoporosis (bone thinning); increased risk of breast cancer; menstrual irregularities — Abdominal pain, weight gain, nervousness — Limit use to less than 2 years; do not give in pregnancy or with active liver disease

Norethindrone Ortho Micronor, Errin — Endocrine agent; Progestin

Norethindrone PO/Function/Common Use PO — Mimics progesterone — Contraception

Norethindrone Adverse Drug Reactions/Special Considerations Increased risks: breast cancer; menstrual irregularities — Breast tenderness, headache, nausea — Do not give in pregnancy or with active liver disease; must take within 3 hours of scheduled dose

Progesterone Prometrium, Crinone, Endometrin — Endocrine agent; Progestin

Progesterone PO/Function/Common Use PO — Mimics progesterone — Secondary amenorrhea; prevention of endometrial hyperplasia

Progesterone Adverse Drug Reactions/Special Considerations Increased risks: breast cancer; menstrual irregularities — Breast tenderness, headache, nausea — Do not give in pregnancy or with active liver disease; must take within 3 hours of scheduled dose