Central Nervous System Pharmacology (Q7)

Tricyclic antidepressants

Inhibit reuptake of NA and 5-HT to increase neurotransmitter at synapse

Cellular target of Tricyclic antidepressants

NA and 5-HT transport proteins

Side effects of Tricyclic antidepressants

Withdrawal symptoms, sedation

Example of Tricyclic antidepressants

Imipramine

Selective serotonin reuptake inhibitors

Selectively inhibit 5-HT reuptake to increase neurotransmitters at synapse

Cellular target of Selective serotonin reuptake inhibitors

5-HT transport proteins

Side effects of Selective serotonin reuptake inhibitors

Withdrawal symptoms, sleep disturbances

Example of Selective serotonin reuptake inhibitors

Sertraline

Monoamine oxidase inhibitors

Inhibit MAO-A and MAO-B to increase 5-HT and NA

Cellular target of Monoamine oxidase inhibitors

Intracellular MAO-A and MAO-B isoenzymes

Side effects of Monoamine oxidase inhibitors

Withdrawal symptoms, sleep disturbances, tyramine

Example of Monoamine oxidase inhibitors

Selegiline

Ketamine

Blocks NMDA receptor to increase glutamate transmission

Cellular target of Ketamine

NMDA receptors

Side effects of Ketamine

Delirium, cognitive issues

Example of Ketamine

Esketamine (spravato)