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telomerase stuff
leading strand replication
processive process
lagging strand synthesis problem
needs RNA primers , end up with a gap
DNA gets shorter at 3’ end every cycle of replication
how do bacteria cope with end replication problem
with a circular genome, there is no end
why did we evolve away from circular DNA
too much torsion
telomeres
repeats, protect the genome from end replication problems
poxvirus DNA replication
dsDNA
enzymes that covalently closes the genome between 5’ and 3’
terminal loop removes 3’ hydroxyl
basically all leading strand synthesis
self priming mechanism
problem+ solution in poxvirus DNA replication
both copies of DNA are linked together, use resolves to separate the two
Adenovirus and
