Anatomy L5 - Neural crest cells

Neural crest cells

• ectodermal derivative

• formed dorsal area of NT

• BMPs difine the region that will become NCC

• Migrate and diffrentate into different cells

• Form glial and neurons of parasympathetic, sympathetc and sensory NS

Fate of the Neural Crest Along the Rostro-caudal axis

When NCC migrate away form Neural tube…

• they undergo a epithilial mesenchymal trasition (EMT)

• When these cells migrate away they get exposed to different signals causing them to lineage restrict and become a certain type of cell

NCC that remain in the sclerotome become…

Dorsal root ganglia which then lineage restrict to form proprioceptive sensory neurons

NCC that migrate Dorsal lateraly become….

melonocytes of skin

NCC that migrate ventralateraly form..

go to doral aorta and form adrenal medulla cells

Where do NCC enter the somite

enter theough anterior portion of somite

NCC that continus to move through somite become…

support cells for PNS e.g Schwann cells

Proprioceptive Sensory Neurons

Tap on muscle in knee causes small elongation of muscle which then causes  the sensory neuron to fire an action potential causing motor neuron to then also fire an action potential which then leads to contraction of the muscle

What gives rise to Schwann cells

A subset of glial cells (from the neural crest) give rise to these myelinating Schwann cells

How schwan cells made

• Swhann cell precursers migrate until find axon

• axon tells it what to do

• Glial growth factor expressed by motor neuron and neurons in periphery ganglia stimulate proliferationa and diffrentation