Exam 1 Pathopharm 400

Beta-adrenergic blockers (MEDs)

Timolol, Carteolol, Metipranolol, Levobunolol

Beta-adrenergic blockers MOA

Decreased IOP by decreasing the amount of aqueous humor produced.

Cardioselective B1 Blocker

Betaxolol

Cardioselective B1 Blocker MOA

Decreased IOP by decreasing the amount of aqueous humor produced

Alpha2 Adrenergic agonists (MEDs)

Brimonidine, Apraclonidine

Alpha2 Adrenergic agonists MOA

Decreases production while increasing outflow of aqueous humor to lower IOP

Alpha2/BB (MEDs)

Brimonidine and Timolol

Alpha2/BB MOA

decreases production while increasing outflow of aqueous humor to lower IOP

Prostaglandin Analog (MEDs)

Latanoprost, Travoprost, Bimatoprost

Prostaglandin Analog MOA

Reduces IOP by increasing aqueous humor outflow through relaxation of ciliary muscle

Osmotic Agent (MEDs)

Mannitol

Osmotic Agents MOA

Decreases IOP by making the plasma hypertonic, thus drawing fluid from the anterior chamber of the eye

Carbonic anhydrase inhibitor (MEDs)

Acetazolamide, Methazolamide

Carbonic anhydrase inhibitor MOA

Reduces production of aqueous humor by causing diuresis through renal effects.

Carbonic anhydrase inhibitor (2nd-line topical meds)

Dorzolamide

Direct-acting cholinergic (muscarinic) agonist (2nd-line topical meds)

Pilocarpine