Cells from the Myeloid Progenitor: Lecture 4: Cells and Organs of the Immune System

Four main types of cells develop from common myeloid progenitors

Red blood cells, Megakaryocytes, Monocytes, Granulocytes

Megakaryocytes

make platelets for blood clotting

Monocytes

differentiate into macrophages and dendritic cells (DCs)

Granulocytes consist of

Neutrophils, Basophils, Mast cells, Eosinophils

Neutrophils

Phagocytosis and kills pathogens

Basophils

inflammation/allergies

Mast cells

inflammation/allergies

Eosinophils

antiviral activity, anti-parasitic activity

Granules

contain damaging proteins or molecules that are released in response to pathogens and parasites

Neutrophils are the

first responders to infection, and have numerous PRRs to detect pathogens and will release proinflammatory cytokines upon infection

Eosinophils, basophils and mast cells

are important for defense against multicellular parasites and release granule contents into the area around these parasites to damage and kill them

Mast cells are important for

releasers of histamine

Monocytes are a

precursor cell in the blood that migrates to inflammation areas in the tissues to differentiate into different tissue-specific phagocytic cells

Macrophages

can be derived from monocytes from the blood or already be resident in tissue since development

Dendritic cells (DCs)

Arise from both myeloid and lymphoid precursors. The Main role is to sample antigen and pathogens in tissues and carry them to lymph nodes