HEMATOPOIESIS

MESOBLASTIC STAGE

is the first stage of blood cell formation in an embryo.

19TH DAY OF GESTATION

WHEN DOES MESABLOSTIC STAGE STARTS

ERYTHROBLAST

first blood cells formed by the first month of embryonic life

BLOOD ISLAND OF YOLK SAC

Primary site/s of hematopoiesis in megablastic stage

gower 1

2 zeta chains and 2 epsilon chains?

portland

2 zeta chains and 2 gamma chains

gower II

2 alpha chains and 2 epsilon chains

gower 1
portland
gower 2

give the three stages where Embryonic hemoglobin are formed

hepatic stage

is the second stage of hematopoiesis

fetal liver

hepatic stage occurs in the ____

granulocyte and megakaryocyte

3rd month of gestation in hepatic stage what forms ehre

lymphocyte

4th month of gestation in hepatic stage what formed here

monocyte

5th month of gestation in hepatic stage what forms here

lymph node and spleen

What organs begin to play a limited role as secondary lymphoid organs during mid-fetal life of hepatic stage

secondary lymphoid organ

in mid fetal life, the spleen and lymphnpde began to form as what?

granulocyte and megakryocyte
lymphocyte
monocyte

what blood cells formed in hepatic stage

fetal hemoglobin

type of fetal is produced during the 4th month of gestation

fetal hemoglobin

It is the main type of hemoglobin in the fetus.

2 alpha chain + 2 gamma chain

What is the composition of fetal hemoglobin (HbF)?

bone marrow

Myeloid Stage - primary site/s of hematopoiesis

2 alpha chains and 2 beta chains

what is the formula of HB-A1

2 alpha and 2 delta

what is the formula of HB-A2

postnatal hematopoiesis

means blood cell production after birth.

bone marrow

At birth, ______ becomes the only site for RBC production, granulocytes, monocytes, platelets and B lymphocytes

sternum
vertebrae
skull
pelvis
ribs

Hematopoiesis occurs in most bones but primarily in the flat bones of the_ give them all

sternum

In adults, blood cell production mainly occurs in the bone marrow of flat bones specifically in ______

stem cells

Known as pluripotential or multipotential cells
Primary cells

Having capability of self renewal

This can differentiate into many specialized cells

pluripotential and multipotential

stem cells are also known as

non lymphocyte

multipotential stem cells which give rise to

b or t lymphocyte

Secondary multipotential stem cells which give rise to primitive

progenitor (committed) cell

-known as unipotential stem cells-differentiate into only one cell line

designed to form a particular type of cel

lymphoid stem cells
colony forming blastocyte

committed pluripoten hematopoiesis stem cell give rises to 2 groups

Lymphocytes & Natural killer cells

what do you see in Lymphoid stem cells in prgenitor stem cell

colorny forming E, M, GM

Colony forming blastocytes types

ERYTHROCYTE

COLONY FORMING E

MEGAKARYOCYTE

COLONY FORMING M

NEOTROPHILS, EOSINOPHIL, BASOPHIL, MONOCYTE

COLONY FORMING GM

PRO ERYTHROBLAST
EARLY NORMOBLAST
INTERMEDIATE NORMOBLAST
LATE NORMOBLAST
RETICULOCYTE
MATURED RBC

Colony forming unit-E WHATS ITS SEQUENCE

6-8UM

RBC disk diameter

2UM

RBC THICKNESS

4.50 - 6.50 X 10^6 UL

MALE RBC SIZE

3.80UL - 4.80 UL X 10^6

FEMALE RBC SIZE

120 days

rbc life span

wbc

blood cells that fight infection.

4.0 - 11.0 ×10³ ul

ref ranges of wbc

leukocytosis

increased in rbc is called

leukpenia

decreased in rbc is called

granulocyte

Agranulocyte

rbc Sub-divided into two categories viz.