Antibiotics and Toxins Inhibiting Translation

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6 Terms

1
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Streptomycin and other aminoglycosides

Inhibit initiation and cause the misreading of mRNA (prokaryotes

2
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Tetracycline

Binds to the 30S subunit and inhibits the binding of aminoacyl-tRNAs (prokaryotes)

3
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Chloramphenicol

Inhibits the peptidyl transferase activity of the 50S ribosomal subunit (prokaryotes)

4
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Cycloheximide

Inhibits translocation (eukaryotes)

5
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Erythromycin

Binds to the 50S subunit and inhibits translocation (prokaryotes)

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Puromycin

Causes premature chain termination by acting as an analog of aminoacyl-tRNA (prokaryotes and eukaryotes)