INHIBITION OF CELL MEMBRANE & PROTEIN SYNTHESIS

INHIBITION OF CELL MEMBRANE

If the functional integrity of the cytoplasmic membrane is disrupted, macromolecules and ions escape from the cell, and cell damage or death ensues.

Polymyxin E (Colistin)

• Binds to cell membranes rich in phosphatidylethanolamine.

• Active against gram-negative rods, especially P. aeruginosa, Acinetobacter baumannii, and carbapenemase-producing Enterobacteriaceae.

• Bactericidal

Daptomycin

• Induces depolarization of bacterial membrane potential resulting to release of potassium

• This agent is given to organisms highly resistant to βlactam agents and vancomycin.

• Bactericidal

Aminoglycosides

ribosomal subunit: 30s
mode of action: blocks functioning of initiation complex and causes misreading of mRNA
type of activity: bacteriacidal

tetracycline

ribosomal subunit: 30s
mode of action: blocks tRNA binding to ribosome
type of activity: bacteriostatic

tigecycline

ribosomal subunit: 30s
mode of action: blocks protein translation
type of activity: bacteriostatic

chloramphenicol

ribosomal subunit: 50s
mode of action:
type of activity:

Macrolides

ribosomal subunit: 50s
mode of action:
type of activity:

Clindamycin

ribosomal subunit: 50s
mode of action:
type of activity:

linezolid

ribosomal subunit: 30s
mode of action:
type of activity:

quinupristin/dalfopristin

ribosomal subunit: 50s
mode of action:
type of activity:

clindamycin