PHSC1312 Microbiology/Immunology Lecture 14 Helper T Cells

Th1

helper T cell activated in the presence of IFN-gamma and IL-12

Th2

helper T cell activated in the presence of IL-4

Th17

helper T cell activated in the presence of IL-1, IL-6, and IL-23

IFN gamma, IL12

Which cytokines activate Th1 cells? (no hyphens)

IFN gamma

hallmark cytokine of Th1 cells

IL4

Which cytokines activate Th2 cells? (no hyphens)

IL1, IL6, IL23

Which cytokines activate Th17 cells? (no hyphens)

IFN gamma, TNF alpha

Which cytokines are produced by Th1? (no hyphens)

IL4, IL5, IL9, IL13

Which cytokines are produced by Th2? (no hyphens)

IL17, IL21, IL22, IL23

Which cytokines are produced by Th17? (no hyphens)

IL17

hallmark cytokine of Th17 cells

phagocytosis by macrophages, NK cell activation, CD8+ proliferation, IgG production

What are the main functions of Th1 cells?

IgG

main antibody of Th1 cells

macrophages, CTLs, and NK cells

immune cell partners of Th1 cells

B cell proliferation, class switching, IgG, IgA, IgE, mast cell and eosinophil activation

What are the main functions of Th2 cells?

IgE

main antibody of Th2 cells (associated with helminths)

IgG, IgA, IgE

all antibody isotypes Th2 cells can class switch to

mast cells and eosinophils

immune cell partners of Th2 cells

neutrophil activation, support phagocyte mediated elimination of microbes, defensins and other antimicrobials, IgA antibody response

What are the main functions of Th17 cells?

IgA

main antibody of Th17 cells

intracellular bacteria, protozoa, viruses

Th1 cells are primary host immunity effectors against what?

extracellular parasites like helminths, allergic responses

Th2 cells are primary host immunity effectors against what?

extracellular bacteria, fungi

Th17 cells are primary host immunity effectors against what?