Drug Table Week 2

Inflammation Treatment & Anti-Rheumatic Drugs

What is the generic name for Advil/Motrin?

ibuprofen

Name the NSAIDs using generic names?

Ibuprofen, Naproxen, Diclofenac, Meloxicam, Celecoxib

What is the target for NSAIDs?

COX-1 and COX-2

What is the target family for NSAIDs?

Cyclooxygenase

What is the MOA for NSAIDs?

Reversibly inhibits COX-1/COX-2 → Decreases conversion of arachidonic acid into prostaglandins → Decreases prostaglandins-mediated inflammation, pain, and fever

What is ibuprofen intended use?

Non-selective NSAID

Symptomatic pain/inflammation

What is naproxen intended use?

Longer-acting NSAID

Pain/Inflammation Relief

What is diclofenac intended use?

Pain/Inflammation relief

What is meloxicam intended use?

OA/RA pain & inflammation

Preference to COX-2

What is celecoxib intended use?

OA/RA pain & inflammation

Why is Celebrex a special NSAIDs?

Targets only COX-2

Name the NSAIDs using brand names?

Motrin, Aleve, Voltaren, Mobic, Celebrex

What is the generic name for Aleve?

Naproxen

What is the generic name for Voltaren?

Diclofenac

What is the generic name Mobic?

meloxicam

What is the generic name for Celebrex?

Celecoxib

What is the brand name for acetaminophen?

Tylenol

What is the drug group for acetaminophen?

Non-opioid analgesic/ antipyretic

Name the drugs for Glucocorticoid?

Methylprednisolone and Prednisone

What is the drug target for Glucocorticoid?

Glucocorticoid Receptor (GR)

What is the methylprednisone and prednisone intended use?

Rapid suppression of inflammation

What else is methylprednisolone used for?

Infection risk, osteoporosis, adrenal suppression

What is the MOA for methylprednisolone?

Activates GR → alters gene transcription → Decreases production of inflammatory cytokines/mediators

What is the target family for Glucorticoid?

Intracellular/ nuclear receptor

What is the generic name for Medrol?

methylprednisolone

What is the generic name for Plaquenil?

hydroxychloroquine

What is the generic name for Azulfidine EN-tabs?

Sulfasalazine

What is the generic name for Xeljanz?

tofacitinib

What is the generic name Olumiant?

Baricitinib

What is the generic name for Rinvoq?

Upadacitinib

What does the drug ending in ~citinib?

Janus Kinase Inhibitor (JAK) and DMARD

What is hydroxychloroquine used for?

Rheumatoid Arthritis (RA) and Lupus (SLE)

What is sulfasalazine used for?

Rheumatoid Arthritis (RA) and Ulcerative Colitis

What is tofacitinib used for?

Rheumatoid Arthritis (RA)

What is baricitinib used for?

Rheumatoid Arthritis (RA)

What is upadacitinib used for?

Rheumatoid Arthritis (RA)

What is methotrexate used for?

Rheumatoid Arthritis (RA) and Chemotherapy

What are the DMARDs?

Methotrexate, hydroxychloroquine, and sulfasalazine

What is the drug target for hydroxychloroquine?

Endosomal/lysosomal and TLR signaling

What is the drug target for sulfasalazine?

Multiple inflammatory pathways

What is the MOA for hydroxychloroquine?

Increase lysosomal pH → Affects antigen processing and TLR signaling → Decreases inflammatory cytokines

What is the drug target for methotrexate?

Dihydrofolate reductase (DHFR)

What is the MOA for sulfasalazine?

Prodrug → Decrease inflammatory mediator production

What is the MOA for methotrexate for RA?

Increases adenosine signaling → Inhibits inflammatory pathways → Decreases T-cell activity and inflammation

What are the big AE for methotrexate?

Hepatotoxicity and Bone marrow suppression

What are the big AE for hydroxychloroquine?

Retinal toxicity and GI upset

What are the big AE for sulfasalazine?

Bone marrow suppression, GI upset, and rash

What are the big AE for NSAIDs? (4)

GI irritation, ulcer, bleeding, kidney injury → Decreased renal function

What are the big AE for diclofenac?

Hepatotoxicity + cardiovascular risk

What are the big AE for celecoxib?

CV thrombotic risk but less GI toxicity

What are the AEs for glucorticoids?

Weight gain, fluid retention, hyperglycemia

Name the drugs from the drug family JAK inhibitors?

tofacitinib, baricitinib, and upadacitinib

What is the MOA for JAK inhibitors?

Cytokine binds receptor → JAK activation → STAT phosphorylation → STAT into nucleus → Decreases inflammation transcription

What are the major AE for glucocorticoids?

Respiratory infections, blood clots, MACE

What is aspirin drug class?

NSAID, salicylate anti-platelet

What type of inhibitor is aspirin?

Irreversible competitive inhibitor

What is aspirin intended use?

secondary prevention of cardiovascular/cerebrovascular events; pain; fever