Immunology- Cytokines

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Last updated 5:57 AM on 9/12/26
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33 Terms

1
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IL18, IL15, IL22

By macrophages

=Increases NK cells, neutrophils

2
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IL1

Hematopoiesis, more immune cells (chemotraction)

-By macrophages

3
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IL8

More neutrophils, more immune cells (chemotraction)

-By macrophages

4
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TNF alpha

General inflammation

-By macrophages

5
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GM-CSF

Increase macrophages + eosinophils

-By Macrophages

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INT alpha

Antiviral response in cells close by

By Plasmacytoid DC

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IL7

Stimulate pre-B cell and innate lymphoid cells

By Bone marrow

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IL11

Increases hematopoiesis

By bone marrow

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IL13, IL25, IL33

Calls to mast cells and eosinophil

By innate lymphoid cell 2

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IL17, IL22

Production of antimicrobial proteins and defensins by skin and gut mucosa

By innate lymphoid cells 3

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IL8

Chemottraction for Th cells

By Conventional Dendritic cell

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IL4

Activate B cells & IgE synthesis

By eosinophils

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IL5

Calls for eosinophils

By eosinophils

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TNF alpha

enhances inflammation

By eosinophils

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IL13

Airway inflammation & mucus secretion

By eosinophils

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IL12

Tell Th is a virus

By Dendritic cells & macrophages

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IL2

Activate NK, Tc and some B cells

By Th1 (virus)

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IFN gamma

Increase MHC I, MHC II & IgG production

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TNF alpha

Fever and antiviral signaling

By Th1 (virus)

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GM-CSF (viral infection)

Hematopoisis

By Th1

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IL16, IL23, TGF beta

“Is bacteria” to Th0

By dendritic cells & macrophages

22
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IL21 +IL6

21- antibody class switch, activates B cells

6- inhibit Treg differentiation & synergistic with IL21

By Tfh (bacteria)

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IL4

“Eukaryotic pathogen” to Th0

By DC & macrophages

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IL4, IL5, IL13, IL31

By Th2 (eukaryotic)


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IL4

IgE + IgG production in B cells

By Th2

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IL5

IgA production on eosinophils

By Th2

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IL13

Activate mast cells & basophils

By Th2

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IL31

Binds sensory nerves= dermatitis

By Th2

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IL23, IL6, TGF beta

Inhibit Treg cells, activate Th0

By Dendritic cells

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IL17

Increase macrophages and neutrophils

By Th17 (mucosal infection)

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IL22

Stimulate epithelial cells, antimicrobial response (defensins & proteins)

By Th22 (skin)

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IL10, TGF beta, IL35

Inhibit immune cells response

By Treg

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IL10

Block cytokine production

By Treg