DRUGS FOR PERIPHERAL ARTERY DISEASE AND ERECTILE DYSFUNCTION

Intermittent claudication

Peripheral artery disease also known as _____

Peripheral artery disease

It is a pain caused by too little blood flow to muscle during exercise

Atherosclerosis

In the peripheral artery disease_____ can result in ischemia of peripheral muscles just as coronary artery disease causes cardiac ischemia

skeletal muscles: legs / lower extremities

exercise: rest

The pain (claudication) of peripheral artery disease occurs in ____, especially in the _____, during ___ and disappears with ___

It is not immediately life threatening

Peripheral artery disease is not?

Increased mortality

Can severely limit exercise tolerance

and may be associated with chronic ischemic ulcers

and susceptibility to infection

It still requires treatment because peripheral artery disease is associated with?

Primarily directed at reversal or control of atherosclerosis and requires measurement and control of hyperlipidemia, hypertension and obesity; cessation of smoking; and control of diabetes, if present.

Treatment of peripheral artery disease

1. Physical therapy and exercise training is of proven benefit.

2. Conventional vasodilators are no benefit because vessels distal to the obstructive lesions are usually dilated at rest

3. Antiplatelet drugs are often used to prevent
   clotting in the region of plaques

4. Specific drugs- Pentoxyfylline & Cilostazol

Give the approaches treatment for peripheral artery disease

Pentoxyfylline and Cilostazol

Two drugs are used almost exclusively for peripheral artery disease and have vasodilating effects:

Pentoxyfylline

This is thought to act by reducing the viscosity of blood, allowing it to flow more easily through partially obstructed areas

Pentoxyfylline

The only methylxanthine derivative not used for asthma

Phosphodiesterase type 3

• converts cAMP to AMP (inactive)

• increase cAMP = vasodilation, antiplatelet

Both the peripheral artery disease is a type of what inhibitor?

Cilostazol

This drug is poorly understood, but may have selective antiplatelet and vasodilating effects

Pentoxyfylline and Cilostazol

Both drugs have been shown to increase exercise tolerance in patients with severe claudication

PDE-5-inhibitors

PGE-1 analog

Type of drugs used for treatmetn of erectile dysfunction

the prostate, male organs, and urethra, breaks CGMP down to GMP.

• increase CGMP = vasodilation

PDE-5 is present in?

Sildenafil (Viagra)

Tadalafil and Vardenafil

Drugs that is PDE-5

Relaxation permits inflow of blood at nearly arterial pressure into the sinuses of the cavernosa and it is the pressure of the blood that causes erection.

Explain the action of PDE-5

Alprostadil

Drug that is PGE-1 analog

Alprostadil

This is a drug for patent ductus arteriosus palliative therapy

Alprostadil

This drug is injected directly into the cavernosa or placed in the urethra as a mini suppository