8 - Oncology (Absite 2024)

1. Self-sufficiency of growth signals

2. Insensitivity to growth-inhibitory signals

3. Potential for limitless replication

4. Angiogenesis

5. Evasion of apoptosis

6. Invasion & metastasis

The hallmarks of cancer are the following:

1.

2.

3.

4.

5.

6.

RET gene

MEN2 syndrome is associated with gain of function mutation in the ____ gene

TP53

Li-Fraumeni syndrome is associated with mutation of _____ (gene)

p16

Mutations in ____ is associated with melanomas, as well as cancers of the pancreas, esophagus, head and neck, stomach, breast, and colon