Lymphocytes

NK cells

first ILC identified - able to kill virus infected and tumor cells without requiring prior activation

NK cells

Considered to be cytotoxic ILC1s.

cytotoxic ILC1s

NK cells : Considered to be

NK cells

Large, granular lymphocytes

NK cells

Produced by bone marrow stem cells

bone marrow stem cells

NK cells: Produced by —

NK cells

Found in peripheral blood, lymph nodes,spleen and bone marrow but not in thymus.

thymus

NK cells: Found in peripheral blood, lymph nodes,spleen and bone marrow but not in —-

lymphocyte

Small round cells, 7 to µm in diameter

lymphocyte

Single large round nucleus – stain intensely with hematoxylin.

hematoxylin

lymphocyte: Single large round nucleus – stain intensely with —

lymphocyte

Nucleus is surrounded by a thin rim of cytoplasm containing mitochondria, free ribosomes and small golgi apparatus.

lymphocyte

ILCs are often larger.

ILC

— are often larger.

lymphocyte

T and B cells.

B cells

bone marrow, bursa, peyer’s patches

B cells

lymoh node cortex ; splenic follicles

B cells

does not circulate

B cells

BCR- immunoglobuin

BCR

immunoglobulins

B cells

pokeweed, lipopolysaccharide

B cells

free foreign proteins

B cells

difficult tolerance induction

B cells

plasma cells, memory cells

B cells

immunoglobulins

T cells

thymus

T cells

lymph node paracortex ; spleen periarteriolar sheath

T cells

does circulate

T cells

TCR- protein heterodimer

Associated with CD3, CDfour, or CD8

T cells

CD2, CD3, CD4, OR CD8

T cells

phytohemagglutinin, concanavalin A, BCG vaccine, pokeweed

T cells

processed foreign proteins in MHC antigens

T cells

easy

T cells

effector T cells, memory T cells

T cells

cytokines

Cytokine receptors

respond to various cytokines,which are signaling molecules that regulateimmune responses.

cytokines

Cytokine receptors: respond to various — ,which are signaling molecules that regulate immune responses.

Ig receptors

These receptors include both the BCR itself and other receptors that bind immunoglobulins.

BCR , immunoglobulins

Ig receptors: These receptors include both the — itself and other receptors that bind —

Antigen receptor

additional receptors involved in antigen processing and presentation

Complement receptors

on B cells: complement system, enhancing B cell responses and linking innate and adaptive immunity.

Regulatory receptors

- help modulate their activation, proliferation, and function, ensuring appropriate immune responses and preventing autoimmunity.

Transport receptors

- movement and localization of T cells within the body, facilitating their migration to sites of infection ,inflammation, or secondary lymphoid organs.

antigen-receptor complex

The — on T cells, also known as the T cell receptor (TCR) complex responsible for .recognizing antigen presented by APCs

T cell receptor (TCR) complex

The antigen-receptor complex on T cells, also known as the — responsible for .recognizing antigens presented by APCs

APCs

The antigen-receptor complex on T cells, also known as the T cell receptor (TCR) complex responsible for recognizing antigens presented by —

CD4

Only found on T helper cells

CD4

Receptors of MHC class II molecules

CD4

Elevated number indicates increase lymphocyte reactivity.

CD8

Only expressed on T cells that attack and kill abnormal cells (cytotoxic T cells).

CD8

Receptors for MHC Class I molecules

CD8

Elevated number indicates decrease lymphocyte reactivity.