Part 5: org and function of GABAergic system

Where is GABA found

@ internneurons as well as Cortex, hippocampus, substancia nigra, globus pallidus, striatum, and cerebellum

What type of receptor is the GABA A receptor and what channels do they open

Ionotropic and the channels allow Cl- to move from outside to the inside of the cell which hyperpolarizes and inhibits the post-synaptic cell

What is an agonist for the GABA A receptor and what side effect might it cause

Muscimol, hallucinations

What is an antagonist for the GABA A receptor and what is the function

Bicuculline, causes convulsions

What common drugs potentiate GABA at GABA A receptors

Alcohol and barbiturates

What kind of receptor is a GABA B receptor and what channels do they open

Metabotropic, open K+ channels which decreases cAMP and hyperpolarizes the cell

What is an agonist for GABA B receptors and what is the result

Baclofen, relaxes the muscle