Fatty Liver (Stenosis)

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4 Terms

1
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What is the difference between Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH)?

  • NAFLD = fat accumulation in the liver unrelated to alcohol use.

  • NASH = severe form with inflammation, hepatocyte injury, and fibrosis; can progress to cirrhosis and liver cancer.

  • NAFLD = fat only

  • NASH = fat + inflammation + damage

2
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What risk factors increase NAFLD risk?

  • Obesity

  • Type 2 diabetes

  • Metabolic syndrome

  • Hyperlipidemia

  • PNPLA3 gene (common in Latino population)

3
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What labs and imaging are used to diagnose NAFLD/NASH?

  • Elevated ALT/AST

  • MRI

  • Ultrasound (US)

  • Nuclear imaging

  • Liver biopsy

  • Transient elastography

4
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What are the primary interventions for NAFLD/NASH?

  • Lifestyle modifications → weight loss, glucose control, lipid-lowering therapy, diet, exercise, behavioral changes

  • No FDA-approved drug yet