Host Immunoinflammatory Response to Dental Biofilm

This set of flashcards covers key concepts related to the host immunoinflammatory response to dental biofilm and periodontal disease.

What is the primary function of the host response?

The host response primarily functions to recognize and respond to microbial challenges, including the immune and inflammatory responses to protect the body.

Name three factors that can enhance the microbial challenge to the periodontium.

1. Poor oral hygiene 2. Smoking 3. Diabetes.

What is a biochemical mediator?

Biochemical mediators are substances released by cells to regulate immune and inflammatory responses.

Name three types of biochemical mediators.

1. Cytokines 2. Prostaglandins 3. Matrix metalloproteinases (MMPs).

What is the role of cytokines in periodontal disease?

Cytokines play a role in the pathogenesis of periodontitis by promoting inflammation and recruiting immune cells to the site of infection.

How do prostaglandins contribute to periodontitis?

Prostaglandins contribute to the pathogenesis of periodontitis by enhancing inflammation and bone resorption.

What effect do matrix metalloproteinases (MMPs) have on periodontal tissues?

MMPs lead to the degradation of extracellular matrix components, contributing to tissue breakdown and periodontal disease progression.

List the 4 stages in the development of periodontal disease.

1. Initial stage 2. Early stage 3. Established stage 4. Advanced stage.

What happens in the Early Gingivitis Stage?

In the Early Gingivitis Stage, the first clinical signs of gingivitis occur, which may include redness, swelling, and bleeding of the gums.

List four factors influencing a host’s failure to control bacterial challenge.

1. Genetic predisposition 2. Systemic diseases 3. Hormonal changes 4. Nutritional deficiencies.

What is the bone remodeling cycle?

The bone remodeling cycle is the process where bone tissue is continuously renewed through resorption and formation, adapting to changes in mechanical load and systemic factors.