TNM Classification of Larynx Cancer Lecture Notes

Practice flashcards covering TNM staging, grouping, and grading of larynx cancer based on lecture notes.

$$N1$$

Metastasis in a single ipsilateral lymph node, $3\,cm$ or less in greatest dimension.

$$N2$$

Metastasis in a single ipsilateral lymph node, more than $3\,cm$ but not more than $6\,cm$ in greatest dimension, or multi- ple ipsilateral lymph nodes, none more than $6\,cm$ in greatest dimension, or bilateral or contralateral lymph nodes, none more than $6\,cm$ in greatest dimension.

$$N2a$$

Metastasis in a single ipsilateral lymph node more than $3\,cm$ but not more than $6\,cm$ in greatest dimension.

$$N2b$$

Metastasis in multiple ipsilateral lymph nodes, none more than $6\,cm$ in greatest dimension.

$$N2c$$

Metastasis in bilateral or contralateral lymph nodes, none more than $6\,cm$ in greatest dimension.

$$Na$$

Metastasis in a lymph node more than $6\,cm$ in greatest dimension.

$$Mx$$

Distant metastasis cannot be assessed.

$$M0$$

No distant metastasis.

$$M1$$

Distant metastasis.

Stage $0$ Grouping

$Tis$, $N0$, $M0$

Stage $I$ Grouping

$T1$, $N0$, $M0$

Stage $II$ Grouping

$T2$, $N0$, $M0$

Stage $III$ ($T3$, $N0$ variation)

$T3$, $N0$, $M0$

Stage $III$ ($T1$ variation)

$T1$, $N1$, $M0$

Stage $III$ ($T2$ variation)

$T2$, $N1$, $M0$

Stage $III$ ($T3$, $N1$ variation)

$T3$, $N1$, $M0$

Stage $IVA$ ($T48$/$T4a$ variation)

$T48$, $N0$, $M0$ or $T4a$, $N1$, $M0$

Stage $IVA$ ($T1$/$N2$ variation)

$T1$, $N2$, $M0$

Stage $IVA$ ($T2$/$N2$ variation)

$T2$, $N2$, $M0$

Stage $IVA$ ($T3$/$N2$ variation)

$T3$, $N2$, $M0$

Stage $IVA$ ($T4a$/$N2$ variation)

$T4a$, $N2$, $M0$

Stage $IVB$ Grouping

$T4b$, Any $N$, $M0$ or Any $T$, $N3$, $M0$

Stage $IVC$ Grouping

Any $T$, Any $N$, $M1$

Grade $1$

Well differentiated histopathologic grade.

Grade $2$ and Grade $3$

Moderately differentiated ($Grade\,2$) and Poorly differentiated ($Grade\,3$) histopathologic grades.