LAB - Expt. 8

washing hands with plain soap and water

One of the best ways to prevent the spread of infections and decrease the risk of getting sick

20

Washing hands often with soap and water for at least ___ seconds is essential

60 (-80%)

CDC recommends consumers use an alcohol-based hand sanitizer that contains at least ____% alcohol

• portable X-ray fluorometers

• infrared and Raman spectrometers

these testing devices are commonly employed at ports, borders, and security checkpoints

rapid screening

much of the focus recently has been on through-container spectroscopy, because such measurements require no sample preparation and allow analysis without opening and potentially spoiling products

Spatially offset Raman spectroscopy (SORS)

A technique that allows acquisition of a molecular fingerprint spectrum of a product through a container (without the need of opening the container to remove a sample of the product)

Laser radiation

____ from SORS devices can penetrate most plastic and glass containers

Raman spectroscopy

In ______, light that interacts with the chemical bonds of a molecule produces scattered light of frequencies that depend on the nature of the chemical bond.

traditional Raman

In ______, the scattered light is measured at the point at which the laser light enters the sample.

spatially offset Raman

In ______, the scattered light is collected at a lateral offset where photons that travel longer can be detected, and this allows one to obtain information about the molecules at distance from the surface of the container.

• SORS

• vector machine (SVM)-

CDER researchers used _____ and support _____-based regression algorithms to quantify the amounts of alcohol in hand sanitizer formulations in containers of differing material, thickness, or opacity

Formulation review

this review ensures the correct composition of active ingredients

Label review

This review verifies accurate labeling information

Traceability review

This review ensures proper documentation and tracking of the product

Ethanol

• Active ingredient in most hand sanitizers.

• It kills or inactivates a wide range of microorganisms, including bacteria and viruses.

• Provides the antiseptic properties necessary for effective hand sanitization

• used as a stabilizer and to ensure the long-term effectiveness of the sanitizer

• helps prevent bacterial contamination during storage

• assists in maintaining the stability of the formulation.

glycerol

• serves as a humectant

• moisturizes the skin, preventing it from drying out due to repeated use of hand sanitizer

• Enhances the overall skin feel after application

Distilled Water

• used as a diluent to achieve the desired volume

• ensures that the final product has the correct concentration of active ingredients

• Contributes to the overall fluidity of the sanitizer