TCA cycle

Private to acetyl CoA

Step 1 (pre cycle)

Pyruvate dehydrogenase

Enzyme in step 1

CoA- SH and nad+ in, CO2, NADH and H+ out

Step 1 reactants and products

Acetyl CoA und oxaloacetate to citrate

Step 2

Water in, CoA-SH out

Step 2, reactant then product

Citrate synthase

Step 2 enzyme

Citrate to cis-Aconitate

Step 3

Water out

Step 3 product

Aconitase

Step 3 enzyme

Cis-aconitate to D-Isocitrate

Step 4

Water in

Step 4, reactant

Aconitase

Step 4 enzyme

D-isocitrate to a-ketoglutarate

Step 5

Nad+ in, NADH, H+ and CO2 out

Step 5, reactant and products

Isocitrate dehydrogenase

Step 5 enzyme

A-ketoglutarate to succinyl CoA

Step 6

Nad+ and CoA-SH in, NADH, H+ and CO2 out

Step 6 reactants and products

A-ketoglutarate dehydrogenase

Step 6 enzyme

Succinyl CoA to succinate

Step 7

GDP and Pi in, CoA-SH and GTP out

Step 7 reactants and products

Succinyl CoA synthetase

Step 7 enzyme

Succinate to fumarate

Step 8

Q (ubiquinone) in, QH2 (ubiquinol) out

Step 8 reactants and products (using energy from fad+ to FADH2)

Succinic dehydrogenase

Step 8 enzyme

Fumigate to malate

Step 9

Water in

Step 9 reactant

Fumarase

Step 9 enzyme

Malate to Oxaloacetate

Step 10

Nad+ in , NADH and H+ out

Step 10 reactant and products

Malate dehydrogenase

Step 10 enzyme

Citrate, cis-aconitate, d-isocitrate

6 carbons

A ketoglutarate

5 carbons

Succinyl-CoA, succinate, fumarate, malate, oxaloacetate

4 carbons

Acetyl CoA

2 carbons