Neuroendocrine Tumors (NETs)

Octreoscan generic name

In-111 pentetreotide

Octreoscan (In-111 pentetreotide) Physical characteristics

- particle

- t 1/2

- gamma particle

- t 1/2- 2.8 days

Octreoscan (In-111 pentetreotide) kit prep

-Draw up to 8-11 mCi of In-111 Chloride in 3 cc syringe

- QS w/ 1 ml saline

- Inject into Octreoscan vial

- QS vial to 2 ml of saline

- genetly invert vial 6-10 times, incubate for 30 min

- Use within 6 hrs

Octreoscan (In-111 pentetreotide) primary organ

Spleen

Octreoscan (In-111 pentetreotide) physical characteristics

Kit contains 1 cold octreoscan vial

and

5 mCi at calibration date of In-111 chloride

Octreoscan (In-111 pentetreotide) Indication

Assessment of neuroendocrine tumors, also sarcoidosis

Octreoscan (In-111 pentetreotide) MOA

somatostatin binding to receptors, Endocytosis first held by lysosomes then transffered to cell nucleus

Octreoscan (In-111 pentetreotide) dosage

5-6 mCi

Octreoscan (In-111 pentetreotide) QC

Clear

>90%

Detectnet generic name

Cu-64 dotatate

Detectnet (Cu-64 dotatate) indication

Assessment of neuroendocrine tumors

Detectnet (Cu-64 dotatate) MOA

binds to somatostatin receptors, Endocytosis

Detectnet (Cu-64 dotatate) dosage

4-5 mCi