Leukocyes, Hematopoiesis and Leukemia

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32 Terms

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Proliferation pool

Creation (Bone marrow)

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Storage pool

Bone marrow, spleen

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Marginal pool and circulating pool

Blood vessels

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Tissue pools

Tissue

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Leukocytosis

Elevated number of WBC

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What are causes of leukocytosis

Excitement, Muscular exertion, Seizures, Stress, Digestion, Pregnancy, Estrus, Neonates, Species variation, Postimmunization

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Hematopoiesis

Formation of blood cells

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How long do RBC live for?

110 - 122 days in dogs, 68 in cats, 140-150 in horses

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How long do neutrophils live for?

6-7 hours in circulation, 2-3 days in tissue

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How long do eosinophils live for?

6-10 hours in circulation, several weeks in tissue

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How long do Basophils live for?

Few hours in circ, several weeks in tissue

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How long do Monocytes live for?

2 days in circulation, few days to months in tissue

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How long do lymphocytes live for?

6-12 in circulation, months to years in tissue

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How long do platelets live for?

3-7 days

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What are the majority of lymphocytes in the body?

T cells (70% in body)

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Leukemia

Unregulated neoplastic proliferation in marrow

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Lymphoma

Unregulated neoplastic proliferation in lymph nodes

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Acute Leukemia

Infiltration and often replacement of marrow by immature blast cells, death within days or weeks

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Chronic Leukemia

Slow progression, Abnormal cells able to partially or completely mature

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Acute Lumphoid Leukemia (ALL) 

Infiltration with circulating lymphoblasts (B and T cells)

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Acute Myeloproliferative or Nonlymphoid (AML)

Infiltration with blast cells from on myeloid stem cell lines

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Chronic Lymphoid Leukemia (CLL)

Increased proliferation of circulating lymphocytes, normal cells not able to pass out of blood vessels

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Chronic Myelogenous Leukemia (CML)

Marked proliferation of granulocytes, neutrophilia with significant left shift

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Polycythemia Rubra Vera (P Vera)

Overproduction of RBC

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Essential thrombocytosis

Overproduction of platelets

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Lymphoma

solid hematopoietic tumor in dogs and cats, either B-cell or T-cell involved

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Hemoglobin formation begins during the __________ stage of erythrocyte maturation and ends during the
_________ stage.

Rubricyte; metarubricyte

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The primary cytokine involved in the stimulation of erythrocyte production is

Erythropoietin

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The primary cytokine involved in the stimulation of platelet production is:

Thrombopoietin

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The primary cytokine involved in the stimulation of leukocyte production is:

Leukopoietin

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The primary site for the production of blood cells in the neonatal and juvenile animal is:

Red bone marrow