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Proliferation pool
Creation (Bone marrow)
Storage pool
Bone marrow, spleen
Marginal pool and circulating pool
Blood vessels
Tissue pools
Tissue
Leukocytosis
Elevated number of WBC
What are causes of leukocytosis
Excitement, Muscular exertion, Seizures, Stress, Digestion, Pregnancy, Estrus, Neonates, Species variation, Postimmunization
Hematopoiesis
Formation of blood cells
How long do RBC live for?
110 - 122 days in dogs, 68 in cats, 140-150 in horses
How long do neutrophils live for?
6-7 hours in circulation, 2-3 days in tissue
How long do eosinophils live for?
6-10 hours in circulation, several weeks in tissue
How long do Basophils live for?
Few hours in circ, several weeks in tissue
How long do Monocytes live for?
2 days in circulation, few days to months in tissue
How long do lymphocytes live for?
6-12 in circulation, months to years in tissue
How long do platelets live for?
3-7 days
What are the majority of lymphocytes in the body?
T cells (70% in body)
Leukemia
Unregulated neoplastic proliferation in marrow
Lymphoma
Unregulated neoplastic proliferation in lymph nodes
Acute Leukemia
Infiltration and often replacement of marrow by immature blast cells, death within days or weeks
Chronic Leukemia
Slow progression, Abnormal cells able to partially or completely mature
Acute Lumphoid Leukemia (ALL)
Infiltration with circulating lymphoblasts (B and T cells)
Acute Myeloproliferative or Nonlymphoid (AML)
Infiltration with blast cells from on myeloid stem cell lines
Chronic Lymphoid Leukemia (CLL)
Increased proliferation of circulating lymphocytes, normal cells not able to pass out of blood vessels
Chronic Myelogenous Leukemia (CML)
Marked proliferation of granulocytes, neutrophilia with significant left shift
Polycythemia Rubra Vera (P Vera)
Overproduction of RBC
Essential thrombocytosis
Overproduction of platelets
Lymphoma
solid hematopoietic tumor in dogs and cats, either B-cell or T-cell involved
Hemoglobin formation begins during the __________ stage of erythrocyte maturation and ends during the
_________ stage.
Rubricyte; metarubricyte
The primary cytokine involved in the stimulation of erythrocyte production is
Erythropoietin
The primary cytokine involved in the stimulation of platelet production is:
Thrombopoietin
The primary cytokine involved in the stimulation of leukocyte production is:
Leukopoietin
The primary site for the production of blood cells in the neonatal and juvenile animal is:
Red bone marrow