Types of Module 7 Questions and their Equations

Average Plasma Concentration for Oral Multiple Dose Regimen

Cavg = (F* D)/ ( Vd* K*ፒ)

F- Bioavailability Factor

D- Dose

Vd- Volume of Distribution

K - Elimination Rate Constant

ፒ- Frequency Dosing

Average Plasma Concentration for IV Bolus Multiple Dose Regimen

Cavg = (F* D)/ ( Vd* K*ፒ)

F- Bioavailability Factor

D- Dose

Vd- Volume of Distribution

K - Elimination Rate Constant

ፒ- Frequency Dosing

Average Plasma Concentration for IV Infusion Multiple Dose Regimen

Cavg = (F* D)/ ( Vd* K*ፒ)

F- Bioavailability Factor

D- Dose

Vd- Volume of Distribution

K - Elimination Rate Constant

ፒ- Frequency Dosing

VD for IV Bolus

Vd= Dose/ Cp0

Loading Dose ( Always IV)

Desired Conc * Vd/ F

** DO NOT FORGET THE F

Tmax

(lnka- lnk) / ka-k

Pral abosirtion k and ka factor

e^ke - e^ka

Peak Plasma Concentration for IV Infusion Multiple Dose Regimen

D ( 1-e^-kT)/ (Vd * k * T (1- e^- kፒ)

D- Dose

Vd- Volume of Distribution

K - Elimination Rate Constant

T-Infusion Time

ፒ- Frequency Dosing

Peak Plasma Concentration for IV Bolus Multiple Dose Regimen

(D/V) * ( 1/ 1- e^-kፒ)

D- Dose

Vd- Volume of Distribution

K - Elimination Rate Constant

ፒ- Frequency Dosing

Calculate Cmin

Cmax * e^-kፒ

K - Elimination Rate Constant

ፒ- Frequency Dosing

Testing Tip: Write out all steps, Break them up and write them down.

You make common mistakes in downstream calculations

Testing Tip: Write out all steps, Break them up and write them down.

You make common mistakes in downstream calculations

Testing Tip; Re-Punch the calculation at LEAST 3 Times

You make common mistakes in downstream calculations

Testing Tip; Re-Punch the calculation at LEAST 3 Times

You make common mistakes in downstream calculations 0

Plasma Concentration for IV Bolus Multiple Dose Regimen before SS

(D/V) ( ( 1-^-nKelፒ)/( 1-e^-kelፒ) ) e^-kt

D- Dose

Vd- Volume of Distribution

Kel - Elimination Rate Constant

ፒ- Frequency Dosing

t- Time after last dose

n- # of dose

Plasma Concentration for IV Bolus Multiple Dose Regimen after SS

( D/Vd) * ( e^-kt/ 1-e^-kፒ)

D- Dose

Vd- Volume of Distribution

Kel - Elimination Rate Constant

ፒ- Frequency Dosing

t- Time after last dose

Plasma Concentration for IV Infusion Multiple Dose Regimen during infusion

( R/ Vd. k) * (1- e ^ -kt) * ( 1/ (1- e ^ -kፒ)

Exact Maintenance Dose

• Obtain Css form Cavg Equation

  Do = Cl * Css * ፒ/ F

Plasma Concentration for IV Infusion Multiple Dose Regimen after Infusion

( R/ Vd. k) * (1- e ^ -kTinf) ( 1/ (1- e ^ -kt-Tinf) *( 1/ (1- e ^ -kፒ)

R

Dose / ፒ