Topic 8 Cell Cycle & DNA Replication Review

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Biology

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48 Terms

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purpose of cell division?

growth, repair, and reproduction.

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<p> interphase</p>

interphase

longest phase of the cell cycle, consisting of three stages: G1, S, and G2

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<p></p>

G1 - Cell increases in size, preparation for DNA replication, and new organelles/proteins are made

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What is G0

Cells exit the active cell cycle and temporarily stop dividing/cells that don’t do mitosis (nerve cells)

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<p></p>

S - the cell duplicates its entire genome, ensuring that each daughter cell receives an identical copy of the genetic material.

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<p></p>

G2 - Growth and prep for mitosis. Organelles replicated (especially centrioles in animal cells)

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Cyclins

A protein manages cell cycle checkpoints

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<p></p>

Prophase - Chromatin condenses into chromosomes, spindle fibers form and attach to centromeres, centrioles move to opposite poles, nuclear envelope disappears

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<p></p>

Metaphase - chromosomes are moved to metaphase plate. Checkpoint: are spindles attached to all centromeres.

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<p></p>

Anaphase - spindles pull sister chromatids to opposite poles and cell becomes longer

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<p></p>

Telophase - spindle breaks down, cytoplasm cleaves (cleavage furrow), nuclear membrane reforms, chromosomes decondense into chromatin

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<p>cytokinesis phase</p>

cytokinesis phase

Division of cytoplasm and cell membrane resulting in two daughter cells. Animal cells, a cleavage furrow forms and pinches the cell into two. Plant cells, a cell plate forms between the daughter nuclei and develops into a new cell wall.

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purpose of mitosis

Repair tissue, replace cells, growth, asexual reproduction

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chromatin

A mixture of DNA and proteins will form the chromosomes during mitosis

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chromosomes

Chromatin that is condensed intro structures to be used during cell division

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chromatid

One of two identical halves of a chromosome; sister chromatids are identical

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sister chromatids

Identical copies of a chromosome, connected by a centromere.

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centromere

Region where sister chromatids are joined.

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centriole

Organelle involved in spindle fiber formation.

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Spindle fibers

Microtubules that separate sister chromatids during cell division.

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Mitotic Index (not formula)

Measure of the percentage of cells in a population undergoing mitosis

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formula for mitotic index

(number of cells/total number of cells)100

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cancer

Abnormal/uncontrolled cell growth

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<p>characteristics of cancer cells</p>

characteristics of cancer cells

Grow uncontrollably, invade nearby tissues, and spread to other parts of the body. They ignore signals that regulate normal cell division and often carry genetic mutations.

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P53 gene

Tumor suppressor gene involved in regulating cell division and preventing mutations.

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tumor

Abnormal mass of cells.

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contact inhibition

Normal cells stop dividing when they come into contact with other cells, but cancer cells continue to divide uncontrollably.

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DNA

Genetic information in all living organisms

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structure of DNA

Double helix composed of nucleotides.

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base pairing of DNA

Adenine (A) pairs with Thymine (T), and Cytosine (C) pairs with Guanine (G)

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antiparallel

The two strands of DNA run in opposite directions.

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nucleotide structure

Phosphate group, a sugar molecule (deoxyribose 5’ and 3’), and a nitrogenous base.

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DNA replication

Process by which a cell makes an identical copy of its DNA (S phase, nucleus)

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exanucleases

Removes mismatched DNA nucleotides replaces w/ correct ones

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DNA helicase

Unwinds DNA by breaking H-bonds making replication fork

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topoisomerase

Relieves tension from helicase by preventing super-coiling

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single stranded binding proteins (ssbp)

Prevents DNA from reforming after H bonds are broken by helicase

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DNA primase

Builds short sequence of RNA primer on parent strand for DNA polymerase III to bond

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DNA polymerase III

Adds new DNA nucleotides in 5’ to 3’ direction

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nucleoside triphosphates

Nucleotide w/3 phosphastes to provide energy to DNA poly III

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leading strand

New strand built continuously toward replication fork

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lagging strand

New strand built discontinuously in fragments away from replication fork

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DNA polymerase I

Replaces the RNA primer w/DNA nucleotides (one on leading, multiple on lagging)

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DNA ligase

Joins sections of DNA (Okazaki fragments) by forming phosphodiester bonds.

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direction of DNA synthesis

5’ to 3’ direction

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where does DNA polymerase attach

Attaches to the 3’ end of the primer

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Why does DNA elongate in the 5’-->3’ direction?

Due to the structure of the DNA molecule and the directionality of DNA polymerase.

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okazaki fragments

Short segments of DNA that are synthesized discontinuously on the lagging strand during DNA replication.