Other Blood Group Systems

which blood group antigens adsorb onto RBCs

Lewis

which blood group converts as an infant matures

I or i

Why and how is anti-I removed during testing

anti-I may mask clinically significant antibodies; removed by adsorption or prewarming serum and using IgG AHG instead of polyspecific AHG

which antigen deteriorates in strength upon storage

P1

what is the difference between Anti-P1 and Anti-P

Anti-P1 is an IgM cold antibody and not clinically significant; Anti-P is an IgG autoantibody and is found in Paroxysmal Cold Hemoglobinuria

which antibody may be formed by african american individuals who lack S, s, and U

Anti-U

which antigens are inactivated with 2-MF, DTT, or AET

Kell

which antibodies are associated with delayed transfusion reactions

Kidd

which population is more likely to have Duffy antigens

white population

type of exclusion where marker is present in child but absent from mother and father

direct exclusion

type of exclusion where child lacks marker that the alleged father must transmit

indirect exclusion

what are Papain, Bromelin, Ficin and Trypsin

enzymes

Which antibodies are cold

I, M, N, H, P, Le

Which antibodies are warm

Rh, Kell, Duffy, Kidd and S

which antigens are denature by enzymes

Duffy, M, N, S

which antigens are enhanced by enzymes

Kidd, Rh, Lewis

Which antigens are present on cord cells

i

which antibodies are naturally occurring

ABO, Lewis, P, MN, Lu

which antibodies are clinically significant

ABO, Rh, Kell, Duffy, Kidd, SsU

which antibody is associated with cold agglutinin disease and Mycoplasma pneumoniae infections

anti-I

antigen-antibody enhancement that reduces net charge of RBCs

albumin

antigen-antibody enhancement that lowers ionic strength of suspending medium

LISS

antigen-antibody enhancement that increases antibody update; used for detection/ID of weak IgG antibodies

PEG

what antigen does the Mcleod phenotype weaken

Kell

what are the three main high frequency antigens

little k, Lu^b, Kp^b

which antibody may be present in children following a viral infection

autoanti-P

what type of transfusion reaction is caused by HLA antibodies

TRALI

which antibodies react ONLY at the Coombs phase

Duffy, Kell and Kidd

which blood group system may change during pregnancy

Lewis

which Ig class are cold antibodies/ warm antibodies

cold are IgM warm are IgG

which antibody can cause spontaneous abortion

anti-P

why can only IgG antibodies and not IgM antibodies cause HDFN

only IgG antibodies can cross the placenta