IBD (NAPLEX)

What are the 2 major types of IBD?

Ulcerative colitis

Crohn’s Disease

Classic symptom of IBD

Bloody diarrhea

What medication can cause IBD flares?

NSAIDs

Difference between IBD & IBS?

IBS does not cause inflammation

Entire GI tract

A. Ulcerative colitis

B. Crohns disease

B. Crohns disease

Colon and rectum ONLY

A. Ulcerative colitis

B. Crohns disease

A. Ulcerative colitis

Transmural depth

A. Ulcerative colitis

B. Crohns disease

B. Crohns disease

Superficial depth

A. Ulcerative colitis

B. Crohns disease

A. Ulcerative colitis

Continuous

A. Ulcerative colitis

B. Crohns disease

A. Ulcerative colitis

IBD diagnosis

Colonscopy with tissue biopsy

Nonpharm food/drinks IBD

Smaller, more frequent meals that are low in fat and dairy

Drink plenty of water

Acute exacerbation TX

Crohns: steroids

UC: aminosalicylates +/- steriods

Crohns Disease TX ** studygal (mild vs mod-sev disease)

MILD DISEASE: Oral budesonide for <3 months, then d/c or change to thiopurine or MTX

MOD-SEVERE DISEASE:

Anti-TNF +/- MTX or a thiopurine

IL receptor antagonist

Integrin receptor antagonist (Vedolizumab)

Alternatives: JAK inhibitor

Ulcerative colitis TX ** studygal (mild vs mod-sev disease)

MILD DISEASE: Mesalamine (5-ASA)

MOD-SEVERE DISEASE:

Anti-TNF +/- thiopurine

IL receptor antagonist

Integrin receptor antagonist

Oral S1P

Alternative: JAK inhibitor

Budesonide brand

Entocort EC, Uceris

Mesalamine brand names

Pentasa (ER caps)

Enema (Rowasa)

Suppository (Canasa)

Mesalamine suppository needs to be retained for ≥ __-__ hours

1-3

Mesalamine enema needs to be retained _____

overnight

Azathioprine genetic testing

TPMT

Azathioprine is metabolized to ______

mercaptopurine

Natalizumab brand

Tysabri

Natalizumab ___ over 1 hour every ___ weeks

IV

every 4 weeks

Vedolizumab brand

Entyvio, Entyvio Pen

T/F: Vedolizumab comes in IV and SC

True

Vedolizumab should be d/c if no benefit by week ____.

14

What steroids are avaliable as rectal foam products for IBD?

A. Prednisone and budesonide

B. Budesonide and dexamethasone

C. Hydrocortisone and prednsione

D. Hydrocortisone and methylprednisolone

E. Budesonide and hydrocortisone

E. Budesonide and hydrocortisone

side effect of opening Colazal capsules

staining of the teeth/tongue

which integrin receptor antagonist has a REMs program?

natalizumab (Tysabri)