Conventional Anti-inflammatory

Why are RA and OA considered similar?

Increases inflammatory mediators → Increases inflammatory pain

What is the precursor of all eicosanoids?

Arachidonic acid

What three kinds of signals are released after AA is transformed from COX?

Thromboxane A₂, PGE₂, PGI₂,

What does thromboxane A₂ syntheses?

Platelet aggregation and vasoconstriction

How does PGE₂ amplify the pain signal?

Decreases nociceptors activation threshold which increases the ability to excite

What does PGI₂ syntheses?

Vascular endothelium = inhibition of platelet aggregation

What does PGE₂ syntheses?

Mucosal protection & Inflammatory cells → nociceptor sensitization + pro-inflammatory signaling

What is the difference between COX-1 and COX-2?

COX-2 promotes inflammation

COX-1 maintains homeostasis used more with gastric mucosa

What kind of inhibition does ibuprofen do?

Noncovalent inhibition

What kind of inhibition does aspirin do?

Irreversible covalent modification

What is converted into PGE₂?

PGH₂

Define this:

How much more potently a drug inhibits one target than another

Selectivity

Define this:

Less drug required to inhibit that target by 50%

Lower IC₅₀