chapter 31 - acute leukemias

20%

according to WHO classification, except in leukemias with defining genetic abnormalities, the minimal percentage of blasts necessary for a diagnosis of acute leukemia is

AML with CBFB::MYH11 fusion

20 year old px

• elevated WBC count

  • blasts — 70%

  • neutrophils — 4%

  • lymphocytes — 5%

  • monocytes — 21%

• eosinophils with abnormally large, dark purple-violet granules are seen

AML with which karyotypes would be most likely to be seen?

high hyperdiploidy

considered a sign of potentially favorable prognosis in children with ALL

ALL

signs and symptoms of cerebral infiltration with blasts are more commonly seen in

tumor lysis syndrome

an oncology px exhibits sings of renal failure with seizures after initial chemotherapy may potentially develop:

dt(15;17)(q22;q12), PML::RARA

DIC is more often seen in association with leukemia characterized by which mutation?

AML with KMT2a rearrangement

which leukemia affects primarily children

• characterized by increase in monoblasts & monocytes

• often associated with gingival & skin involvement

acute monocytic leukemia

20 year old px

• presents with fatigue, pallor, easy bruising, and swollen gums

• bone marrow examination

  • 82% cells with delicate chromatin

  • prominent nucleoli that are positive for

    • CD14

    • CD4

    • CD11b

    • CD36

which leukemia is likely?

≥80% erythroid cells of which ≥30% are pronormoblasts

WHO diagnostic criteria for acute erythroid leukemia includes which bone marrow findings?

acute megakaryoblastic

px with normal chromosomes

• WBC count — 3.0 × 10⁹/L

• dysplasia in all cell lines

• 60% blasts of varying sizes

  • stain positive for CD61

most likely type of leukemia is?

lipids

SBB stains which component of cells

monocytic

cytochemical stain α-naphthyl butyrate is a nonspecific esterase stain that shows diffuse positivity in cells of which lineage?