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Functions of the liver (6)
1. break down RBC, producing bile pigments
2. secretes bile into duodenum through bile ducts
3. converts amnio acids into urea and glucose
4. stores glucose as glycogen
5. releases glucose
6. produces heparin
The left lobe of the liver is divided into medial and lateral segments by the
left hepatic vein
ligamentum teres
The left lobe of the liver is separated from the caudate lobe by the
ligamentum venosum
The left lobe of the liver is separated from the right lobe superiorly by the _____ and inferiorly by the _____
middle hepatic vein
main lobar fissure
The right lobe of the liver is divided into anterior and posterior segments by the
right hepatic vein
The falciform ligament attaches the liver to the
anterior abdominal wall
The gastrohepatic ligament connects the liver to the
lesser curvature of the stomach
The hepatoduodenal ligament connects the liver to the
proximal duodenum
The ligamentum teres lies within what structure, and what was it previously
falciform ligament
fetal umbilical vein
The triangular ligament is the most lateral portion of what ligament, and what does it connect the liver to
coronary ligament
body wall
What is the ligamentum venosum
obliterated ductus venosum
Where does the hepatic artery enter the liver, how much of the liver's blood supply is through the hepatic artery, it lies _____ to the common hepatic duct and _____ to the main portal vein, what is normal diameter
porta hepatis
30%
medial
anterior
2-4mm
The left portal vein divides into:
The right portal vein divides into:
How much of the liver's blood supply is through the portal veins, what kind of blood does it transport to the liver, what should diameter never exceed
left medial and lateral portal veins
right anterior and posterior veins
70%
nutrient rich (oxygen poor) blood from GI tract
13mm
Is the liver intraperitoneal or extraperitoneal
intraperitoneal
Causes of hepatomegaly (7)
1. congestive heart failure
2. inflammatory processes
3. polycystic disease
4. fatty infiltration
5. biliary obstruction
6. neoplasm
7. budd-chiari syndrome
Symptoms of hepatomegaly (3)
asymptomatic
RUQ pain
RUQ mass
Portal vein sonographically
hyper echoic walls
hepatopedal flow
Indications for examination of liver (7)
1. abnormal liver function tests
2. hepatocellular disease
3. biliary disease
4. abdominal pain
5. postprandial pain
6. palpable liver or spleen
7. pancreatitis
Symptoms of hepatic cyst (2)
asymptomatic
dull RUQ pain
Hepatic cyst sonographically (5)
anechoic
round or oval shape
well-defined
posterior acoustic enhancement
may contain septations or low-level internal echoes
What is a cystedenoma, what age group and gender is it more common in
rare, benign neoplasm containing cystic structures within the lesion
middle-aged women
Symptoms of Cystadenoma (2)
hepatomegaly
palpable RUQ mass
Cystadenoma Sonographically (4)
multiloculated cystic mass
well-defined margins
thin septations
thick septations/mural nodules suspicious for malignancy
What is Polycystic disease of the liver, what age group and gender is it more common in
inherited cystic disorder
middle aged females
Polycystic disease of the liver symptoms (4)
asymptomatic
hepatomegaly
palpable RUQ mass
RUQ pain
Polycystic disease of the liver sonographically (3)
multiple cystic structures
posterior acoustic enhancement
multiple cysts may also be found in kidneys, pancreas, spleen
Causes of hepatic abscess (5)
ascending cholangitis
recent travel abroad
biliary infection
appendicitis
diverticulitis
Hepatic abscess symptoms (7)
abdominal pain
fever
chills
leukocytosis
elevated alkaline phosphatase
jaundice
hepatomegaly
Hepatic abscess sonographically (5)
complex mass
oval/round shape
irregular wall margins
usually solitary
posterior acoustic enhancement
Hepatic candidiasis cause
fungal infection
Hepatic candidiasis symptoms (5)
immune-suppressed patient
abdominal pain
fever
chills
palpable liver
Hepatic candidiasis sonographically (5)
hypoechoic
thick wall
hepatomegaly
target or "wheel within a wheel"
hyper echoic lesions with posterior acoustic shadowing
Echinococcal cyst cause
parasite (echinococcus granulosum)
recent travel to underdeveloped countries
Echinococcal cyst symptoms (5)
RUQ pain
leukocytosis
fever
hepatomegaly
elevated alkaline phosphatase
Echinococcal cyst sonographically (6)
septated cystic mass (honeycomb)
mobile internal echoes (snowflakes)
cyst containing smaller daughter cysts
collapsed cyst within a cyst (water lily sign)
round/oval shape
smooth wall margins
Hepatitis A cause
viral infection
Hepatitis B cause
viral infection transmitted by infected blood/body fluids
Hepatitis C cause
dirty needle from blood transfusion
Hepatitis Symptoms (6)
fatigue
loss of appetite
fever
chills
nausea
non obstructive jaundice
Hepatitis sonographically (5)
normal to hypoechoic liver parenchyma
prominent portal veins (starry night)
hepatomegaly
splenomegaly
increased parenchymal echogenicity (chronic cases)
What is peliosis hepatitis
rare disorder in chronically ill patients
Peliosis hepatitis symptoms
hepatomegaly
Peliosis hepatitis sonographically
focal or diffuse cystic liver masses
necrotic, blood-filled liver spaces communicating with hepatic veins
Schistosomiasis cause
parasite entering skin
Schistosomiasis symptoms
rash
fever
diarrhea
lymphadenopathy
RUQ pain
Schistosomiasis sonographically
increased echogenicity of portal walls
thick portal walls
atrophied right lobe
hypertrophied left lobe
thickened gallbladder wall
portosystemic collaterals
Cause of hepatic adenoma
long history of use of oral contraceptives
Hepatic adenoma symptoms
asymptomatic
normal labs
RUQ pain
Hepatic adenoma sonographically
solid, slightly hypoechoic mass
hypoechoic halo
complex mass with hemorrhage and necrosis
What is the most common benign liver mass
cavernous hemangioma
What is a cavernous hemangioma, what gender is it more common in
benign congenital neoplasm consisting of large blood-filled cystic spaces
females
Cavernous hemangioma symptoms
asymptomatic
RUQ pain
Cavernous hemangioma sonographically
homogenous
hyper echoic mass
well-defined
round
may increased in size
Cirrhosis causes (7)
1. alcoholism
2. chronic hepatitis C
(two most common cause in US)
3. biliary obstruction
4. viral hepatitis
5. budd-chiari syndrome
6. nutritional deficiencies
7. cardiac disease
Cirrhosis symptoms (8)
1. weakness
2. fatigue
3. abdominal pain
4. ascites
5. skin changes
6. hair loss
7. nonobstructive jaundice
8. elevated aspartate amniotransferase, alanine amniotransferase, and bilirubin
Cirrhosis sonographically (7)
1. increased parenchymal echogenicity
2. irregular nodular contour
3. inability to distinguish portal vein wall margins
4. sound attenuation
5. enlarged caudate lobe
6. splenomegaly
7. ascites
Fatty infiltration causes (8)
1. obesity
2. diabetes
3. cirrhosis
4. hepatitis
5. alcohol abuse
6. hyperlipidemia
7. metabolic disorder
8. ulcerative colitis
Fatty infiltration symptoms
asymptomatic
elevated liver function tests
hepatomegaly
Fatty infiltration sonographically
increased parenchymal echogenicity
normal vessel wall margins
normal liver parenchyma appears as hypoechoic mass adjacent to IVC or anterior to portages hepatis
What is the second most common benign liver mass
focal nodular hyperplasia
Focal nodular hyperplasia cause, typical symptom
hormone influence, congenital vascular malformation
asymptomatic
Focal nodular hyperplasia sonographically
hyperechoc or isoechoic liver mass
well-defined
sub capsular location
hypoechoic central stellate scar
peripheral/central blood flow
What is glycogen storage disease, what is the most common type
autosomal recessive disorder of excessive deposition of glycogen in liver, kidneys, and GI tract
type I-Von Gierke disease
Glycogen storage disease symptoms
hepatomegaly
stunted growth
kidney failure
hypoglycemia
bruising
osteoporosis
Glycogen storage disease sonographically
diffuse increase in liver echogenicity
increased attenuation
hepatomegaly
solid liver masses
What is the most common symptomatic vascular tumor in infancy, what is its usual symptom
hemangioendothelioma
abdominal mass
Hemangioendothelioma sonographically
multiple hypoechoic lesions
multiple peripheral vessels
large draining veins with dilated proximal abdominal aorta with AV shunting
What is hemochromatosis
rare disease with excess iron deposits throughout body
Hemochromatosis symptoms
fatigue
SOB
heart palpitations
chronic abdominal pain
Hemochromatosis sonographically
hepatomegaly
increased echogenicity
What is a mesenchymal hamartoma
rare lesion occurring in children less than 2 years of age
Mesenchymal hamartoma symptoms
abdominal distension
palpable abdominal mass
Mesenchymal hamartoma sonogaphically
well-defined
large
complex
anechoic
lace like configuration
Hemangiosarcoma causes
exposure to:
arsenic
polyvinyl
thorotrast
Hemangiosarcoma symptoms
abdominal pain
loss of appetite
lethargy
Hemangiosarcoma sonographically
heterogeneous
hyper echoic mass
cystic mass with septations
internal blood flow
What is the most common malignant tumor in children 3 years old or less
hepatoblastoma
Hepatoblastoma symptoms
abdominal distension
nausea
vomiting
weight loss
precocious puberty
elevated AFP
Hepatoblastoma sonographically
heterogeneous
hyper echoic mass
cystic mass with internal septations
low resistance internal arterial flow
Hepatocellular carcinoma causes
cirrhosis
chronic hepatitis B
exposure to carcinogens
Hepatocellular carcinoma symptoms
palpable mass
abdominal pain
weight loss
fever
jaundice
elevated alanine amniotransferase, aspartate amniotransferase, alkaline phosphatase, and alpha-fetoprotein
Hepatocellular carcinoma sonographically
solid mass
variable echogenicity
possibly hypoechoic halo
hepatomegaly
ascites
multiple nodules or diffuse infiltrative masses
Where does the metastases to the liver usually come from
colon
pancreas
breast
lung
Metastases to the liver symptoms
hepatomegaly
RUQ pain
weight loss
loss of appetite
jaundice
increased in AST, ALT, bilirubin, and alkaline phosphatase
Metastases to the liver sonographically
bull's eye/target lesion
hyper echoic masses
cystic masses
complex masses
diffuse pattern
Budd-Chiari syndrome causes (4)
1. hepatocellular carcinoma
2. tumor extension
3. hematologic disorder
4. congenital webbing of IVC or right atrium
Budd-Chiari syndrome symptoms
abdominal pain
hepatomegaly
lower-extremity edema
increased alkaline phosphatase
Budd-Chiari syndrome sonographically (8)
1. thrombus in hepatic and portal veins
2. dilated hepatic veins
3. vein wall thickening
4. absence/altered hepatic venous flow
5. hepatomegaly
6. enlarged caudate lobe
7. ascites
8. hyper echoic liver
Portal hypertension causes (5)
1. cirrhosis
2. hepatitis
3. fatty infiltration
4. portal vein obstruction
5. Budd-Chiari syndrome
Portal hypertension symptoms
splenomegaly
hepatomegaly
elevated LFTs
hematemesis
jaundice
abdominal distension
Portal hypertension sonographically (7)
1. MPV>13mm
2. splenomegaly
3. ascites
4. splenic and SMV>10mm
5. hepatofugal, pulsatile, decreased velocity in portal vein
6. collaterals
7. RI >0.8 in hepatic artery
Portal vein thrombosis causes (6)
1. hepatocellular carcinoma
2. liver metastasis
3. sepsis
4. blood coagulation disorders
5. cirrhosis
6. idiopathic
What is trans jugular intrahepatic portosystemic shunt (TIPS)
shunt placed between a portal and hepatic vein
Normal Gray Scale findings of TIPS
echogenic, non shadowing, tubular structure
connects portal vein to right hepatic vein
8-12mm diameter
Normal Doppler findings of TIPS
MPV: hepatopedal flow
20-60cm/s
R/LPV: hepatofugal flow
peak flow velocity in stent 65-225cm/s
Portal hypertension collaterals
coronary vein
gastroesophageal
mesoenterocaval
paraumbilical vein
splenorenal
Portal hypertension portal caval shunts
mesocaval
portacaval
splenorenal