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substitution
one base is replaced by another- can be silent, missense or nonsense
insertion
one or more bases added, can cause a frameshift
deletion
one or more bases removed, can cause a frameshift
silent
base changes, but amino acid stays the same, usually no change to protein
missense
base change causes a different amino acid, may change protein function
nonsense
base change creates a stop codon, protein is shortened and often non functional
frameshift
insertion/ deletion shifts the reading frame, usually changes many amino acids downstream