PNN - CH. 3 - HIV

HIV markers

gp41 and gp120

Host cell receptors

CD4 and CCR5

Binding Inhibitors (entry inhibitors)

• Ibalizumab-uiyk (Trogarzo) - blocks CD4 receptor

• Selzentry (Maraviroc) - blocks CCR5 receptor

Fusion Inhibitor (Entry inhibitors)

Enfuviritide (Fuzeon) (targets gp41)

NRTIs - ZALES DT

• Zidovudine (AZT, ZDV) (Retrovir)

• Abacavir (ABC) (Ziagen)

• Lamivudine (3TC) (Epivir)

• Emtricitabine (FTC) (Emtriva)

• Stavudine (d4T) (Zerit)

• Didanosine (ddl) (Videx)

• Tenofovir

Integrase Inhibitors - RBED

• Raltegravir (Isentress) (RAL)

• Bictegravir

• Elvitefravir

• Dolutegravir (Tivicay) (DTG)

NNRTIs - RNEEDD

• Rilpivirine (RPV) (Edurant)

• Nevirapine (NVP) (VIramune)

• Efavirenz (EFV) (Sustiva)

• Etravirine (ETR) (Intelence)

• Doravirine (Pifeltro)

• Delavirdine (DLV) (Rescriptor)

Protease Inhibitors - LAND FIRST

• Lopinavir/Ritonavir (RTV) (Kaletra)

• Atazanvir (ATZ) (Reyataz) w/ cobicstat (Evotaz)

• Nelfinavir (NPV) (Viracept)

• Darunavir (DRV) (Prezista)

• Fosamprenavir (FPV) (Lexiva)

• Indavir (IDV) (Crixivan)

• Ritonavir (RTV) (Norvir)

• Saquinavir (SQV) (Invirase)

• Tipranavir (TPV) (Aptivus)

Where each drug works diagram part 1

Where each drug works diagram part 2

CD4 We want to be:

HIGH

Viral Load we want to be:

UNDETECTABLE

HIV life cycle steps

1. Binding

2. fusion

3. reverse transcription

4. integration

5. replication

6. assembly

7. budding

What test do we do before giving Selzentry (Maraviroc)?

tropism test