Communication cellulaire - cdk-cyclines

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Cdk activating kinase (CAK)

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7 Terms

1

Cdk activating kinase (CAK)

phosphoryle un site activateur des CDKs

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2

Wee1 kinase

phosphoryle un site inhibiteur des CDKs, impliquĂ© dans l’inhibition de CDK1 en prĂ© mitose

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3

Cdc25 phosphatase

enlĂšve le phosphate inhibiteur des CDKs, contrĂŽle de l’activation des CDK en prĂ©mitose

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4

p21

supprrime l’activitĂ© des G1/S CDKs et S CDKs suite Ă  des lĂ©sions ADN

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5

p16

supprime l’activitĂ© des G1-CDK, frĂ©quemment inacttivĂ©e par les cancers

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6

APC/C

catalyse l’ubiquitination de protĂ©ines rĂ©gulatrices impliquĂ©es dans la sortie de mitose, rĂ©gulĂ©e par association des sous unitĂ©s activatrices

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7

Cdc20

catalyse l’ubiquitination de protĂ©ines rĂ©gulatrices impliquĂ©es dans le contrĂŽle de G1, phosphorylation des protĂ©iness cibles requises

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