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Last updated 12:51 AM on 9/15/26
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200 Terms

1
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1. The endocrine system works most closely with which system to maintain homeostasis?

A) Digestive

B) Nervous

C) Respiratory

D) Skeletal

B) Nervous
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2. Which statement correctly describes endocrine glands?

A) They contain ducts

B) They secrete only enzymes

C) They are ductless and release hormones internally

D) They release substances onto body surfaces

C) They are ductless and release hormones internally
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3. Compared with the nervous system, endocrine responses are generally:

A) Faster and shorter

B) Slower and longer-lasting

C) Faster and longer-lasting

D) Identical

B) Slower and longer-lasting
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4. A cell responds to a hormone only if it:

A) Contains hemoglobin

B) Has the appropriate receptor

C) Is located next to the gland

D) Is a blood cell

B) Has the appropriate receptor
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5. A decrease in the number of hormone receptors on a target cell is called:

A) Up-regulation

B) Down-regulation

C) Amplification

D) Antagonism

B) Down-regulation
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6. Up-regulation occurs when a target cell:

A) Decreases receptor number

B) Increases receptor number

C) Stops producing ATP

D) Destroys the hormone

B) Increases receptor number
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7. Which is a lipid-soluble hormone?

A) Insulin

B) Growth hormone

C) Cortisol

D) ADH

C) Cortisol
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8. Which class of hormones usually binds to receptors inside target cells?

A) Water-soluble hormones

B) Lipid-soluble hormones

C) Protein hormones only

D) Peptide hormones only

B) Lipid-soluble hormones
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9. Water-soluble hormones generally bind to receptors located:

A) In the nucleus

B) In the cytoplasm

C) On the plasma membrane

D) On DNA

C) On the plasma membrane
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10. Which second messenger is commonly used by water-soluble hormones?

A) DNA

B) cAMP

C) ATP synthase

D) Hemoglobin

B) cAMP
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11. Most lipid-soluble hormones travel in the blood:

A) Attached to transport proteins

B) Inside platelets

C) Completely dissolved in water

D) Inside leukocytes

A) Attached to transport proteins
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12. Most water-soluble hormones travel in blood:

A) Bound to albumin

B) Unattached in plasma

C) Bound to hemoglobin

D) Inside RBCs

B) Unattached in plasma
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13. Most hormone secretion is controlled by:

A) Positive feedback

B) Negative feedback

C) Blood clotting

D) Osmosis only

B) Negative feedback
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14. Which is a classic example of positive feedback?

A) Insulin secretion

B) Thyroid hormone regulation

C) Oxytocin during labor

D) Cortisol regulation

C) Oxytocin during labor
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15. The hypothalamus controls the anterior pituitary primarily through the:

A) Coronary circulation

B) Hypophyseal portal system

C) Pulmonary circuit

D) Hepatic portal system

B) Hypophyseal portal system
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16. Which anterior pituitary hormone stimulates the thyroid gland?

A) TSH

B) ACTH

C) FSH

D) ADH

A) TSH
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17. ACTH primarily stimulates the:

A) Thyroid gland

B) Adrenal cortex

C) Pancreas

D) Pineal gland

B) Adrenal cortex
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18. Which hormone stimulates follicle development in females and sperm production in males?

A) FSH

B) TSH

C) ACTH

D) ADH

A) FSH
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19. Which hormone triggers ovulation in females?

A) Prolactin

B) LH

C) TSH

D) ADH

B) LH
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20. Prolactin primarily promotes:

A) Milk production

B) Milk ejection

C) Uterine contraction

D) Water reabsorption

A) Milk production
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21. Oxytocin is responsible for:

A) Milk production only

B) Milk ejection and uterine contraction

C) Decreasing blood calcium

D) Raising blood glucose

B) Milk ejection and uterine contraction
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22. ADH primarily acts on the:

A) Stomach

B) Collecting tubules of the kidneys

C) Thyroid

D) Testes

B) Collecting tubules of the kidneys
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23. Which hormone helps regulate the sleep-wake cycle?

A) Melatonin

B) Insulin

C) Aldosterone

D) Glucagon

A) Melatonin
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24. Which pancreatic hormone lowers blood glucose?

A) Glucagon

B) Insulin

C) Cortisol

D) Epinephrine

B) Insulin
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25. Which pancreatic hormone raises blood glucose?

A) Insulin

B) Calcitonin

C) Glucagon

D) Melatonin

C) Glucagon
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26. Blood is classified as which type of tissue?

A) Epithelial

B) Connective

C) Muscle

D) Nervous

B) Connective
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27. Which is NOT one of the major functions of blood?

A) Transport

B) Regulation

C) Protection

D) Production of digestive enzymes

D) Production of digestive enzymes
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28. Approximately what percentage of whole blood is plasma?

A) 25%

B) 45%

C) 55%

D) 75%

C) 55%
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29. Approximately what percentage of whole blood consists of formed elements?

A) 10%

B) 25%

C) 45%

D) 65%

C) 45%
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30. The percentage of blood volume occupied by RBCs is called the:

A) Hemoglobin

B) Hematocrit

C) Buffy coat

D) Plasma fraction

B) Hematocrit
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31. The buffy coat consists mainly of:

A) RBCs only

B) Plasma proteins

C) WBCs and platelets

D) Albumin and fibrinogen

C) WBCs and platelets
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32. The most abundant component of plasma is:

A) Protein

B) Water

C) Glucose

D) Sodium

B) Water
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33. Which plasma protein is most important for maintaining blood osmotic pressure?

A) Albumin

B) Fibrinogen

C) Hemoglobin

D) Insulin

A) Albumin
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34. Which plasma protein is important in blood clotting?

A) Albumin

B) Fibrinogen

C) Globin

D) Myosin

B) Fibrinogen
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35. Which formed element is most numerous?

A) Platelets

B) WBCs

C) RBCs

D) Monocytes

C) RBCs
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36. Mature red blood cells lack:

A) Hemoglobin

B) Plasma membrane

C) A nucleus

D) Cytoplasm

C) A nucleus
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37. The primary function of hemoglobin is to transport:

A) Glucose

B) Oxygen

C) Hormones

D) Antibodies

B) Oxygen
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38. Each hemoglobin molecule can carry a maximum of how many oxygen molecules?

A) 1

B) 2

C) 4

D) 8

C) 4
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39. The average lifespan of a circulating RBC is approximately:

A) 10 days

B) 30 days

C) 120 days

D) 1 year

C) 120 days
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40. Erythropoietin is primarily produced by the:

A) Liver

B) Kidneys

C) Spleen

D) Heart

B) Kidneys
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41. Erythropoietin stimulates the production of:

A) Platelets

B) RBCs

C) Antibodies

D) Plasma proteins

B) RBCs
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42. Blood cell formation is called:

A) Hemostasis

B) Hemopoiesis

C) Hemolysis

D) Agglutination

B) Hemopoiesis
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43. In adults, most blood cell formation occurs in:

A) Yellow bone marrow

B) Red bone marrow

C) Cartilage

D) Lymph

B) Red bone marrow
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44. Which cell is a precursor to both myeloid and lymphoid stem cells?

A) Platelet

B) Pluripotent stem cell

C) Neutrophil

D) Reticulocyte

B) Pluripotent stem cell
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45. Which WBC is most strongly associated with bacterial phagocytosis?

A) Neutrophil

B) Basophil

C) Eosinophil

D) Lymphocyte

A) Neutrophil
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46. Which WBC is especially important in fighting parasitic infections?

A) Monocyte

B) Eosinophil

C) Basophil

D) Neutrophil

B) Eosinophil
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47. Which WBC releases histamine and heparin?

A) Basophil

B) Neutrophil

C) Lymphocyte

D) Monocyte

A) Basophil
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48. Monocytes can differentiate into:

A) Platelets

B) Macrophages

C) RBCs

D) Plasma proteins

B) Macrophages
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49. Platelets are best described as:

A) Complete cells with nuclei

B) Cell fragments

C) Plasma proteins

D) Lymphocytes

B) Cell fragments
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50. A person with type A blood has:

A) A antigen and anti-B antibodies

B) B antigen and anti-A antibodies

C) Both antigens and no antibodies

D) No antigens

A) A antigen and anti-B antibodies
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51. A person with type AB blood has:

A) No A or B antigens

B) Both A and B antigens

C) Only A antigen

D) Only B antigen

B) Both A and B antigens
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52. In an RBC transfusion, type O blood is often called the:

A) Universal recipient

B) Universal donor

C) Rh donor

D) Plasma donor

B) Universal donor
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53. Rh-positive blood means the RBCs:

A) Lack Rh antigen

B) Have Rh antigen

C) Lack hemoglobin

D) Contain anti-Rh antibodies

B) Have Rh antigen
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54. Agglutination during an incompatible transfusion refers to:

A) RBC production

B) RBC clumping

C) Platelet formation

D) Plasma dilution

B) RBC clumping
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55. The final meshwork that stabilizes a blood clot is formed by:

A) Albumin

B) Fibrin

C) Globulin

D) Hemoglobin

B) Fibrin
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56. The heart is located primarily in the:

A) Abdominal cavity

B) Mediastinum

C) Pelvic cavity

D) Cranial cavity

B) Mediastinum
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57. About two-thirds of the heart lies:

A) Right of the midline

B) Left of the midline

C) Above the clavicles

D) Below the diaphragm

B) Left of the midline
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58. The pointed inferior portion of the heart is the:

A) Base

B) Apex

C) Septum

D) Hilum

B) Apex
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59. The outermost layer of the heart wall is the:

A) Endocardium

B) Myocardium

C) Epicardium

D) Fibrous pericardium

C) Epicardium
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60. The thick muscular layer of the heart wall is the:

A) Epicardium

B) Myocardium

C) Endocardium

D) Serous pericardium

B) Myocardium
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61. The layer lining the chambers of the heart is the:

A) Endocardium

B) Myocardium

C) Epicardium

D) Fibrous pericardium

A) Endocardium
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62. The fibrous pericardium primarily:

A) Produces blood

B) Prevents overstretching and anchors the heart

C) Conducts impulses

D) Pumps blood

B) Prevents overstretching and anchors the heart
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63. Pericardial fluid primarily functions to:

A) Increase friction

B) Reduce friction

C) Increase blood pressure

D) Generate heart sounds

B) Reduce friction
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64. Which chamber receives blood from the superior and inferior venae cavae?

A) Left atrium

B) Right atrium

C) Left ventricle

D) Right ventricle

B) Right atrium
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65. Blood flows from the right atrium into the right ventricle through the:

A) Mitral valve

B) Tricuspid valve

C) Aortic valve

D) Pulmonary valve

B) Tricuspid valve
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66. Blood leaves the right ventricle through the:

A) Aortic valve

B) Pulmonary semilunar valve

C) Mitral valve

D) Tricuspid valve

B) Pulmonary semilunar valve
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67. Oxygenated blood from the lungs returns to the heart through the:

A) Pulmonary arteries

B) Pulmonary veins

C) Venae cavae

D) Coronary sinus

B) Pulmonary veins
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68. Blood flows from the left atrium to the left ventricle through the:

A) Tricuspid valve

B) Pulmonary valve

C) Mitral valve

D) Aortic valve

C) Mitral valve
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69. Blood leaves the left ventricle through the:

A) Pulmonary trunk

B) Aorta

C) Superior vena cava

D) Coronary sinus

B) Aorta
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70. Which chamber has the thickest myocardium?

A) Right atrium

B) Left atrium

C) Right ventricle

D) Left ventricle

D) Left ventricle
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71. The left ventricle has a thicker wall because it must:

A) Pump blood only to the lungs

B) Pump blood through systemic circulation

C) Receive venous blood

D) Produce electrical impulses

B) Pump blood through systemic circulation
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72. Chordae tendineae and papillary muscles help prevent:

A) Semilunar valve opening

B) AV valve prolapse

C) Atrial contraction

D) Blood entering coronary arteries

B) AV valve prolapse
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73. Which structure is the natural pacemaker of the heart?

A) AV node

B) SA node

C) Bundle branches

D) Purkinje fibers

B) SA node
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74. What is the correct conduction pathway?

A) AV node → SA node → Purkinje fibers → AV bundle

B) SA node → AV node → AV bundle → bundle branches → Purkinje fibers

C) Purkinje fibers → SA node → AV node

D) SA node → Purkinje fibers → AV node

B) SA node → AV node → AV bundle → bundle branches → Purkinje fibers
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75. The delay at the AV node allows:

A) Ventricles to contract before atria

B) Atria to finish contracting before ventricles

C) Blood to bypass the atria

D) Semilunar valves to remain closed permanently

B) Atria to finish contracting before ventricles
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76. On an ECG, the P wave represents:

A) Ventricular depolarization

B) Atrial depolarization

C) Ventricular repolarization

D) Atrial repolarization only

B) Atrial depolarization
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77. The QRS complex represents:

A) Atrial depolarization

B) Ventricular depolarization

C) Ventricular repolarization

D) SA node firing only

B) Ventricular depolarization
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78. The T wave represents:

A) Ventricular repolarization

B) Atrial depolarization

C) Ventricular depolarization

D) AV node delay

A) Ventricular repolarization
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79. The long refractory period of cardiac muscle prevents:

A) Blood flow

B) Tetanic contraction

C) Depolarization

D) ATP formation

B) Tetanic contraction
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80. The right side of the heart pumps blood through the:

A) Systemic circuit

B) Pulmonary circuit

C) Coronary circuit only

D) Hepatic portal circuit

B) Pulmonary circuit
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81. The left side of the heart pumps blood through the:

A) Pulmonary circuit

B) Systemic circuit

C) Renal circuit only

D) Coronary sinus

B) Systemic circuit
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82. The myocardium receives oxygenated blood from the:

A) Pulmonary arteries

B) Coronary arteries

C) Venae cavae

D) Coronary sinus

B) Coronary arteries
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83. The coronary sinus drains directly into the:

A) Left atrium

B) Right atrium

C) Left ventricle

D) Aorta

B) Right atrium
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84. A myocardial infarction occurs when:

A) Blood flow to cardiac muscle is blocked long enough to cause tissue death

B) Heart rate temporarily rises

C) A valve opens normally

D) An atrium depolarizes

A) Blood flow to cardiac muscle is blocked long enough to cause tissue death
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85. Increased venous return generally causes stroke volume to:

A) Decrease

B) Increase

C) Stop

D) Remain permanently unchanged

B) Increase
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86. Increased arterial pressure creates greater:

A) Preload

B) Afterload

C) Venous return

D) Heart rate

B) Afterload
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87. Sympathetic stimulation generally causes heart rate to:

A) Decrease

B) Increase

C) Stop

D) Become zero

B) Increase
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88. Parasympathetic stimulation of the heart generally causes heart rate to:

A) Increase

B) Decrease

C) Double

D) Remain unchanged

B) Decrease
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89. Arteries are defined as vessels that carry blood:

A) Toward the heart

B) Away from the heart

C) Only oxygenated blood

D) Only deoxygenated blood

B) Away from the heart
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90. Veins are defined as vessels that carry blood:

A) Away from the heart

B) Toward the heart

C) Only oxygenated blood

D) Only through the lungs

B) Toward the heart
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91. Which blood vessels are the major sites of exchange between blood and tissues?

A) Arteries

B) Veins

C) Capillaries

D) Aorta

C) Capillaries
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92. What is the correct vessel sequence?

A) Vein → artery → capillary

B) Artery → arteriole → capillary → venule → vein

C) Capillary → artery → arteriole → vein

D) Arteriole → artery → vein

B) Artery → arteriole → capillary → venule → vein
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93. The innermost layer of a blood vessel is the:

A) Tunica interna

B) Tunica media

C) Tunica externa

D) Myocardium

A) Tunica interna
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94. The tunica media contains mainly:

A) Skeletal muscle

B) Smooth muscle

C) Cardiac muscle

D) Adipose tissue

B) Smooth muscle
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95. Vasoconstriction causes the vessel lumen to:

A) Increase in diameter

B) Decrease in diameter

C) Disappear permanently

D) Fill with lymph

B) Decrease in diameter
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96. Vasodilation causes the vessel lumen to:

A) Decrease

B) Increase

C) Close completely

D) Become rigid

B) Increase
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97. Arterioles are especially important for regulating:

A) Blood cell production

B) Blood flow into capillary beds

C) Antibody production

D) Urine storage

B) Blood flow into capillary beds
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98. Precapillary sphincters regulate:

A) Blood flow through capillaries

B) Heart conduction

C) Lymph production

D) RBC lifespan

A) Blood flow through capillaries
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99. Elastic arteries are important because they:

A) Contain valves

B) Stretch during systole and recoil during diastole

C) Exchange gases directly

D) Produce RBCs

B) Stretch during systole and recoil during diastole
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100. Which vessel type generally contains valves to prevent backflow?

A) Arteries

B) Veins

C) Capillaries

D) Arterioles

B) Veins