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1. The endocrine system works most closely with which system to maintain homeostasis?
A) Digestive
B) Nervous
C) Respiratory
D) Skeletal
2. Which statement correctly describes endocrine glands?
A) They contain ducts
B) They secrete only enzymes
C) They are ductless and release hormones internally
D) They release substances onto body surfaces
3. Compared with the nervous system, endocrine responses are generally:
A) Faster and shorter
B) Slower and longer-lasting
C) Faster and longer-lasting
D) Identical
4. A cell responds to a hormone only if it:
A) Contains hemoglobin
B) Has the appropriate receptor
C) Is located next to the gland
D) Is a blood cell
5. A decrease in the number of hormone receptors on a target cell is called:
A) Up-regulation
B) Down-regulation
C) Amplification
D) Antagonism
6. Up-regulation occurs when a target cell:
A) Decreases receptor number
B) Increases receptor number
C) Stops producing ATP
D) Destroys the hormone
7. Which is a lipid-soluble hormone?
A) Insulin
B) Growth hormone
C) Cortisol
D) ADH
8. Which class of hormones usually binds to receptors inside target cells?
A) Water-soluble hormones
B) Lipid-soluble hormones
C) Protein hormones only
D) Peptide hormones only
9. Water-soluble hormones generally bind to receptors located:
A) In the nucleus
B) In the cytoplasm
C) On the plasma membrane
D) On DNA
10. Which second messenger is commonly used by water-soluble hormones?
A) DNA
B) cAMP
C) ATP synthase
D) Hemoglobin
11. Most lipid-soluble hormones travel in the blood:
A) Attached to transport proteins
B) Inside platelets
C) Completely dissolved in water
D) Inside leukocytes
12. Most water-soluble hormones travel in blood:
A) Bound to albumin
B) Unattached in plasma
C) Bound to hemoglobin
D) Inside RBCs
13. Most hormone secretion is controlled by:
A) Positive feedback
B) Negative feedback
C) Blood clotting
D) Osmosis only
14. Which is a classic example of positive feedback?
A) Insulin secretion
B) Thyroid hormone regulation
C) Oxytocin during labor
D) Cortisol regulation
15. The hypothalamus controls the anterior pituitary primarily through the:
A) Coronary circulation
B) Hypophyseal portal system
C) Pulmonary circuit
D) Hepatic portal system
16. Which anterior pituitary hormone stimulates the thyroid gland?
A) TSH
B) ACTH
C) FSH
D) ADH
17. ACTH primarily stimulates the:
A) Thyroid gland
B) Adrenal cortex
C) Pancreas
D) Pineal gland
18. Which hormone stimulates follicle development in females and sperm production in males?
A) FSH
B) TSH
C) ACTH
D) ADH
19. Which hormone triggers ovulation in females?
A) Prolactin
B) LH
C) TSH
D) ADH
20. Prolactin primarily promotes:
A) Milk production
B) Milk ejection
C) Uterine contraction
D) Water reabsorption
21. Oxytocin is responsible for:
A) Milk production only
B) Milk ejection and uterine contraction
C) Decreasing blood calcium
D) Raising blood glucose
22. ADH primarily acts on the:
A) Stomach
B) Collecting tubules of the kidneys
C) Thyroid
D) Testes
23. Which hormone helps regulate the sleep-wake cycle?
A) Melatonin
B) Insulin
C) Aldosterone
D) Glucagon
24. Which pancreatic hormone lowers blood glucose?
A) Glucagon
B) Insulin
C) Cortisol
D) Epinephrine
25. Which pancreatic hormone raises blood glucose?
A) Insulin
B) Calcitonin
C) Glucagon
D) Melatonin
26. Blood is classified as which type of tissue?
A) Epithelial
B) Connective
C) Muscle
D) Nervous
27. Which is NOT one of the major functions of blood?
A) Transport
B) Regulation
C) Protection
D) Production of digestive enzymes
28. Approximately what percentage of whole blood is plasma?
A) 25%
B) 45%
C) 55%
D) 75%
29. Approximately what percentage of whole blood consists of formed elements?
A) 10%
B) 25%
C) 45%
D) 65%
30. The percentage of blood volume occupied by RBCs is called the:
A) Hemoglobin
B) Hematocrit
C) Buffy coat
D) Plasma fraction
31. The buffy coat consists mainly of:
A) RBCs only
B) Plasma proteins
C) WBCs and platelets
D) Albumin and fibrinogen
32. The most abundant component of plasma is:
A) Protein
B) Water
C) Glucose
D) Sodium
33. Which plasma protein is most important for maintaining blood osmotic pressure?
A) Albumin
B) Fibrinogen
C) Hemoglobin
D) Insulin
34. Which plasma protein is important in blood clotting?
A) Albumin
B) Fibrinogen
C) Globin
D) Myosin
35. Which formed element is most numerous?
A) Platelets
B) WBCs
C) RBCs
D) Monocytes
36. Mature red blood cells lack:
A) Hemoglobin
B) Plasma membrane
C) A nucleus
D) Cytoplasm
37. The primary function of hemoglobin is to transport:
A) Glucose
B) Oxygen
C) Hormones
D) Antibodies
38. Each hemoglobin molecule can carry a maximum of how many oxygen molecules?
A) 1
B) 2
C) 4
D) 8
39. The average lifespan of a circulating RBC is approximately:
A) 10 days
B) 30 days
C) 120 days
D) 1 year
40. Erythropoietin is primarily produced by the:
A) Liver
B) Kidneys
C) Spleen
D) Heart
41. Erythropoietin stimulates the production of:
A) Platelets
B) RBCs
C) Antibodies
D) Plasma proteins
42. Blood cell formation is called:
A) Hemostasis
B) Hemopoiesis
C) Hemolysis
D) Agglutination
43. In adults, most blood cell formation occurs in:
A) Yellow bone marrow
B) Red bone marrow
C) Cartilage
D) Lymph
44. Which cell is a precursor to both myeloid and lymphoid stem cells?
A) Platelet
B) Pluripotent stem cell
C) Neutrophil
D) Reticulocyte
45. Which WBC is most strongly associated with bacterial phagocytosis?
A) Neutrophil
B) Basophil
C) Eosinophil
D) Lymphocyte
46. Which WBC is especially important in fighting parasitic infections?
A) Monocyte
B) Eosinophil
C) Basophil
D) Neutrophil
47. Which WBC releases histamine and heparin?
A) Basophil
B) Neutrophil
C) Lymphocyte
D) Monocyte
48. Monocytes can differentiate into:
A) Platelets
B) Macrophages
C) RBCs
D) Plasma proteins
49. Platelets are best described as:
A) Complete cells with nuclei
B) Cell fragments
C) Plasma proteins
D) Lymphocytes
50. A person with type A blood has:
A) A antigen and anti-B antibodies
B) B antigen and anti-A antibodies
C) Both antigens and no antibodies
D) No antigens
51. A person with type AB blood has:
A) No A or B antigens
B) Both A and B antigens
C) Only A antigen
D) Only B antigen
52. In an RBC transfusion, type O blood is often called the:
A) Universal recipient
B) Universal donor
C) Rh donor
D) Plasma donor
53. Rh-positive blood means the RBCs:
A) Lack Rh antigen
B) Have Rh antigen
C) Lack hemoglobin
D) Contain anti-Rh antibodies
54. Agglutination during an incompatible transfusion refers to:
A) RBC production
B) RBC clumping
C) Platelet formation
D) Plasma dilution
55. The final meshwork that stabilizes a blood clot is formed by:
A) Albumin
B) Fibrin
C) Globulin
D) Hemoglobin
56. The heart is located primarily in the:
A) Abdominal cavity
B) Mediastinum
C) Pelvic cavity
D) Cranial cavity
57. About two-thirds of the heart lies:
A) Right of the midline
B) Left of the midline
C) Above the clavicles
D) Below the diaphragm
58. The pointed inferior portion of the heart is the:
A) Base
B) Apex
C) Septum
D) Hilum
59. The outermost layer of the heart wall is the:
A) Endocardium
B) Myocardium
C) Epicardium
D) Fibrous pericardium
60. The thick muscular layer of the heart wall is the:
A) Epicardium
B) Myocardium
C) Endocardium
D) Serous pericardium
61. The layer lining the chambers of the heart is the:
A) Endocardium
B) Myocardium
C) Epicardium
D) Fibrous pericardium
62. The fibrous pericardium primarily:
A) Produces blood
B) Prevents overstretching and anchors the heart
C) Conducts impulses
D) Pumps blood
63. Pericardial fluid primarily functions to:
A) Increase friction
B) Reduce friction
C) Increase blood pressure
D) Generate heart sounds
64. Which chamber receives blood from the superior and inferior venae cavae?
A) Left atrium
B) Right atrium
C) Left ventricle
D) Right ventricle
65. Blood flows from the right atrium into the right ventricle through the:
A) Mitral valve
B) Tricuspid valve
C) Aortic valve
D) Pulmonary valve
66. Blood leaves the right ventricle through the:
A) Aortic valve
B) Pulmonary semilunar valve
C) Mitral valve
D) Tricuspid valve
67. Oxygenated blood from the lungs returns to the heart through the:
A) Pulmonary arteries
B) Pulmonary veins
C) Venae cavae
D) Coronary sinus
68. Blood flows from the left atrium to the left ventricle through the:
A) Tricuspid valve
B) Pulmonary valve
C) Mitral valve
D) Aortic valve
69. Blood leaves the left ventricle through the:
A) Pulmonary trunk
B) Aorta
C) Superior vena cava
D) Coronary sinus
70. Which chamber has the thickest myocardium?
A) Right atrium
B) Left atrium
C) Right ventricle
D) Left ventricle
71. The left ventricle has a thicker wall because it must:
A) Pump blood only to the lungs
B) Pump blood through systemic circulation
C) Receive venous blood
D) Produce electrical impulses
72. Chordae tendineae and papillary muscles help prevent:
A) Semilunar valve opening
B) AV valve prolapse
C) Atrial contraction
D) Blood entering coronary arteries
73. Which structure is the natural pacemaker of the heart?
A) AV node
B) SA node
C) Bundle branches
D) Purkinje fibers
74. What is the correct conduction pathway?
A) AV node → SA node → Purkinje fibers → AV bundle
B) SA node → AV node → AV bundle → bundle branches → Purkinje fibers
C) Purkinje fibers → SA node → AV node
D) SA node → Purkinje fibers → AV node
75. The delay at the AV node allows:
A) Ventricles to contract before atria
B) Atria to finish contracting before ventricles
C) Blood to bypass the atria
D) Semilunar valves to remain closed permanently
76. On an ECG, the P wave represents:
A) Ventricular depolarization
B) Atrial depolarization
C) Ventricular repolarization
D) Atrial repolarization only
77. The QRS complex represents:
A) Atrial depolarization
B) Ventricular depolarization
C) Ventricular repolarization
D) SA node firing only
78. The T wave represents:
A) Ventricular repolarization
B) Atrial depolarization
C) Ventricular depolarization
D) AV node delay
79. The long refractory period of cardiac muscle prevents:
A) Blood flow
B) Tetanic contraction
C) Depolarization
D) ATP formation
80. The right side of the heart pumps blood through the:
A) Systemic circuit
B) Pulmonary circuit
C) Coronary circuit only
D) Hepatic portal circuit
81. The left side of the heart pumps blood through the:
A) Pulmonary circuit
B) Systemic circuit
C) Renal circuit only
D) Coronary sinus
82. The myocardium receives oxygenated blood from the:
A) Pulmonary arteries
B) Coronary arteries
C) Venae cavae
D) Coronary sinus
83. The coronary sinus drains directly into the:
A) Left atrium
B) Right atrium
C) Left ventricle
D) Aorta
84. A myocardial infarction occurs when:
A) Blood flow to cardiac muscle is blocked long enough to cause tissue death
B) Heart rate temporarily rises
C) A valve opens normally
D) An atrium depolarizes
85. Increased venous return generally causes stroke volume to:
A) Decrease
B) Increase
C) Stop
D) Remain permanently unchanged
86. Increased arterial pressure creates greater:
A) Preload
B) Afterload
C) Venous return
D) Heart rate
87. Sympathetic stimulation generally causes heart rate to:
A) Decrease
B) Increase
C) Stop
D) Become zero
88. Parasympathetic stimulation of the heart generally causes heart rate to:
A) Increase
B) Decrease
C) Double
D) Remain unchanged
89. Arteries are defined as vessels that carry blood:
A) Toward the heart
B) Away from the heart
C) Only oxygenated blood
D) Only deoxygenated blood
90. Veins are defined as vessels that carry blood:
A) Away from the heart
B) Toward the heart
C) Only oxygenated blood
D) Only through the lungs
91. Which blood vessels are the major sites of exchange between blood and tissues?
A) Arteries
B) Veins
C) Capillaries
D) Aorta
92. What is the correct vessel sequence?
A) Vein → artery → capillary
B) Artery → arteriole → capillary → venule → vein
C) Capillary → artery → arteriole → vein
D) Arteriole → artery → vein
93. The innermost layer of a blood vessel is the:
A) Tunica interna
B) Tunica media
C) Tunica externa
D) Myocardium
94. The tunica media contains mainly:
A) Skeletal muscle
B) Smooth muscle
C) Cardiac muscle
D) Adipose tissue
95. Vasoconstriction causes the vessel lumen to:
A) Increase in diameter
B) Decrease in diameter
C) Disappear permanently
D) Fill with lymph
96. Vasodilation causes the vessel lumen to:
A) Decrease
B) Increase
C) Close completely
D) Become rigid
97. Arterioles are especially important for regulating:
A) Blood cell production
B) Blood flow into capillary beds
C) Antibody production
D) Urine storage
98. Precapillary sphincters regulate:
A) Blood flow through capillaries
B) Heart conduction
C) Lymph production
D) RBC lifespan
99. Elastic arteries are important because they:
A) Contain valves
B) Stretch during systole and recoil during diastole
C) Exchange gases directly
D) Produce RBCs
100. Which vessel type generally contains valves to prevent backflow?
A) Arteries
B) Veins
C) Capillaries
D) Arterioles